From October 28 to 29, the 12th Paul Walden Symposium took place virtually. The Paul Walden Symposium on Organic Chemistry has become a tradition. It

A multi-target approach in drug discovery is a promising approach in drug discovery. It is the opposite of the traditional path and paradigm of ligand-receptor

The review article summarizing the current progress, challenges and future perspectives on C–H bond functionalization by high-valent cobalt catalysis by Liene Grigorjeva’s group (Organic Synthesis

Greater celandine (Chelidonium majus L.) is a widely distributed valuable medicinal plant. In traditional medicine, this plant has been used to treat bile and liver

The review by scientists from the Latvian Institute of Organic Synthesis and Department of Regenerative Medicine of State Research Institute Centre for Innovative Medicine (Vilnius,

Researchers at the Latvian Institute of Organic Synthesis (Pharmacomodulators synthesis group) have developed a method for cardiolipin (CL) quantitative analysis and therefore have highlighted using

Researchers at the Laboratory of Pharmaceutical Pharmacology (Latvian Institute of Organic Synthesis) have proposed a novel pharmacological approach to increase levels of polyunsaturated fatty acids.

Researchers from groups led by Dr. Emilio Parisini (LIOS, Biotechnology group) and Dr. Olga Bruno have designed, synthesized, and performed the biological evaluation and structural

Enantiopure secondary alcohols are valuable intermediates in medicinal chemistry since many marketed drugs such as crizotinib, lorlatinib, cenobamate, atomoxetine, and duloxetine are derivatives of chiral

Propylamycin is a next-generation aminoglycoside antibiotic that displays increased antibacterial potency. But due to the hydroxy group in propylamycin 5′′-position, it is inactivated by aminoglycoside

Researcher group from Latvian Institute of Organic Synthesis have investigated the molecular mechanisms of cellular insulin resistance. They discovered that long-chain acylcarnitines decrease phosphorylation of

The Covid-19 pandemic is one of the greatest challenges modern medicine has ever faced. While repurposing studies of existing drugs haven’t shown very promising results,

Ansis Maleckis (Latvian Institute of Organic Synthesis), Iresha D. Herath  and  Gottfried Otting (Australian National University) have demonstrated the use of 13C labeled indoles and

Researchers at the Organic Synthesis Methodology Group (Latvian Institute of Organic Synthesis) and the Francis Crick Institute have designed potential drug-like compounds which effectively block

A straightforward and atom‐economic method for the functionalization of short selenocystine‐containing peptides proposed by researchers from the Pharmacomodulators Synthesis Group (LIOS) has been published in

The stereoselective total synthesis of the proposed structure of a potent serotonin 5-HT1A receptor agonist uncarialin A elaborated by LIOS scientists have been published in

Joint research on the electrosynthesis of hypervalent bromine by Edgars Suna and Igors Sokolovs (IOS, Laboratory of Advanced Technologies for Organic Synthesis) and scientists from

A review article on isolation, chemistry, and biology of pyrrolo[1,4]benzodiazepine natural products by Gints Smits group (Laboratory of CNS Active Compounds) has been published in

Researchers from the Pharmacomodulators Synthesis Group (LIOS) have demonstrated a convenient one-pot process for the construction of selanyl and tellanyl substituted N-polyaromatic systems (up to

Joint research on the structural analysis of an antigen chemically‐coupled on virus‐like particles by Kristaps Jaudzems (IOS, Laboratory of Physical Organic Chemistry) and scientists from