Pharmacology and Biological Studies

The biological activity testing subunits in IOS have highly skilled research staff and up-todate equipment to perform both independent pharmacological studies and to assist medicinal chemists by activity screening tests. Pharmacological experiments are followed by in-depth analysis of the obtained tissue samples in collaboration with analytical units of IOS.

The typical biological activity testing services at IOS include:
  • screening of compounds in the test systems selected by the customerand development of screening systems for new indications
  • investigations on the mechanismsof action of active ingredients
  • biochemical measurements, radioligand binding studies, molecular biology assays, immunohistochemisty
  • in vitro experiments in cell culture and isolated organs
  • cardiovascular pharmacology in small experimental laboratory animals
  • CNS activity testing in vivo
  • anticancer activity screening in vitro and in vivo
  • drug metabolism and pharmacokinetics
  • toxicology tests