The biological activity testing subunits in IOS have highly skilled research staff and up-todate equipment to perform both independent pharmacological studies and to assist medicinal chemists by activity screening tests. Pharmacological experiments are followed by in-depth analysis of the obtained tissue samples in collaboration with analytical units of IOS.
The typical biological activity testing services at IOS include:
- screening of compounds in the test systems selected by the customerand development of screening systems for new indications
- investigations on the mechanismsof action of active ingredients
- biochemical measurements, radioligand binding studies, molecular biology assays, immunohistochemisty
- in vitro experiments in cell culture and isolated organs
- cardiovascular pharmacology in small experimental laboratory animals
- CNS activity testing in vivo
- anticancer activity screening in vitro and in vivo
- drug metabolism and pharmacokinetics
- toxicology tests