Our young researchers under Janis Veliks supervision have published a case study which showed that fluorocyclopropane analogue of the anticancer drug cabozantinib shows improved selectivity

Scientists from the Laboratory of Pharmaceutical Pharmacology & Laboratory of Physical Organic Chemistry have published studies of metformin, the most widely prescribed oral medication for

Liene Grigorjeva (Organic Synthesis Methodology Group) has published a review article in the journal “Organic & Biomolecular Chemistry” (IF=3.490, 2019). This review summarizes the C–H

Open Access journal Catalysts (IF = 3.520) has published joint review article from the Laboratory of Membrane Active Compounds and β-diketones (LIOS), State Research Institute

Continuing studies of electrophilic fluorination of heterocycles, Dr. Nadia Pikun with her colleagues from the Laboratory of Membrane Active Compounds and β-diketones has elaborated  a

Continuing studies on eleganine A total synthesis, Dr. Smits (Laboratory of CNS Active Compounds) and Dr. Zemribo elaborated a new synthetic approach towards the core

Research against resistance to β-lactam antibacterials by Dr. Trapencieris group and colleagues from the University of Oxford, University of Leeds, and Jacobs University Bremen has

Dr. Dace Rasiņa et.al. (Organic Synthesis Methodology group) have published a concise bioinspired semisynthesis of rumphellaones A–C and their C-8 epimers from β-caryophyllene in the

Dr. Pavel Arsenyan group elaborated a fast and convenient methodology for the preparation of 10-nonyl acridine orange (NAO) and its silyl analogues to improve their

Researchers from the Laboratory of Pharmaceutical Pharmacology have shown that empagliflozin treatment preserves mitochondrial fatty acid oxidation in the heart under conditions of chronic lipid

Continuing studies of carbonic anhydrase (CA) inhibitors, professors Raivis Žalubovskis’ (LIOS) and Claudiu T. Supuran’s groups showed that clinically used antibiotic Furagin and its derivatives

Dr. Domracheva et.al. have published studies about novel 4-pyridinio-1,4-dihydropyridine (1,4-DHP) derivatives possessing calcium channel modulating activity.  The antagonist, agonist, and dual-action effect of the 1,4-DHP

Dr. Grigorjeva et.al. (Organic Synthesis Methodology group) have developed an efficient method for the synthesis of 3-hydroxymethyl isoindolinones via cobalt-catalyzed C(sp2)–H carbonylation of phenylglycinol derivatives using

Dr. Grigorjeva et.al. (Organic Synthesis Methodology group) have developed a new method for cobalt catalyzed C(sp2)-H functionalization of phenylglycinol derivatives with terminal and internal alkynes

Scientists from the Pharmacomodulators Synthesis group (LIOS) together with authors from the Kaunas University of Technology, KTH Royal Institute of Technology, Bohdan Khmelnytsky National University

Scientists from the Pharmacomodulators Synthesis group together with authors from the Kaunas University of Technology published a joint article on the synthesis of fused chalcogenophenocarbazoles

Scientists from the Laboratory of Pharmaceutical Pharmacology together with authors from 7 other countries published a joint review on how mitochondria are functioning in the

Dr. Veliks et.al. have published a synthetic methodology of synthesis of a range of monofluoro-cyclopropane derivatives in the journal “Organic & Biomolecular Chemistry” (IF=3.490, 2018).

Despite extensive research efforts, very few markers are used in clinics for the diagnosis of type 2 diabetes mellitus. While fatty acid intermediates have been