News

THIOREDIN project discovers the novel derivatives of dithiodiglycolic acid as TrxR1 inhibitors

The Journal of Enzyme Inhibition and Medicinal Chemistry (IF 2017: 3.638) published a research paper from ERA.Net RUS Plus Call 2017 “HEALTH” project “Development of thioredoxin reductase inhibitors towards new anticancer agents“:

Olga Bakulina,Anton Bannykh, Mirna Jovanović, Ilona Domračeva, Ana Podolski-Renić, Raivis Žalubovskis, Milica Pešić, Dmitry Dar’in, Mikhail Krasavin.
Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34(1), pp. 665-671, DOI: 10.1080/14756366.2019.1575372

21.02.2019.Zalubovskis

New article in the field of OLED Semiconductors

An article from the partnership of LIOS and Kaunas University of Technology researchers is published in Chemistry-A European Journal (Impact Factor: 5.16 (2017)):

Brigita Vigante, Karolis Leitonas, Dmytro Volyniuk, Viktorija Andruleviciene, Jurate Simokaitiene, Anna Ivanova, Audrius Bucinskas, Juozas V. Grazulevicius, Pavel Arsenyan.

Synthesis of Linear and V‐Shaped Carbazolyl‐Substituted Pyridine‐3,5‐dicarbonitriles Exhibiting Efficient Bipolar Charge Transport and E‐Type Fluorescence Chem. Eur. J. 2018, DOI: 10.1002/chem.201805323

Arsenjans

This research was supported by the project of scientific co-operation program between Latvia, Lithuania and Taiwan “Synthesis and studies of high-triplet-energy materials for blue OLEDs
(grant No. TAP-LLT-2/2017, No LV-LT-TW/2018/11)

 

New research: Design of organic luminescent molecules

Design of organic luminescent molecules is a new research direction at LIOS funded by Taiwan–Lithuania–Latvia Tripartite Cooperation Fund, project “New materials and technologies for very-high color rendering and high sunlight spectrum resemblance OLED lighting sources”.

One of the project results is published in the open access journal RSC Advances (Impact factor: 2.936):

Aggregation induced emission by pyridinium–pyridinium interactions
RSC Adv., 2019, 9, 460-465, DOI: 10.1039/C8RA08771G

RSC_Adv_Leduskrasts

New article in medicinal chemistry from prof. Suna group

The journal Life Science Alliance published research article:

Life_Sci_All

Estelle Dumont, Julia Vergalli, Jelena Pajovic, Satya P BhamidimarriKoldo Morante, Jiajun Wang, Dmitrijs LubriksEdgars Suna, Robert A Stavenger, Mathias Winterhalter, Matthieu Réfrégiers, Jean-Marie Pagès

Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm

The 3rd project Alliance4Life meeting

The 3rd meeting of Alliance4Life  consortium was held in University of Zagreb, School of Medicine in Croatia from 3 to 5 December 2018.

Alliance4Life is consortium of ten research institutions from nine Central and Eastern European countries and it aims at addressing the existing gap in health research and innovation performance between EU15 and EU13 countries.

Three meeting days covered a full agenda with focus group discussions dedicated to the development of best practices, strategies, and policy recommendations for the future operation of the Alliance.

The interested participants attended two training sessions – Modern Trends in HR, and How to Prepare a Successful MSCA-IF Proposal. Also Mr. Telemachou from the European Commission gave a presentation about Sharing Excellence in Horizon Europe.

3rd_A4L_meeting_Zagreb

Just released: Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D

The European Journal of Medicinal Chemistry (IF 2017: 4.816) published a research paper from Latvian Institute of Organic Synthesis, Malaria Biochemistry Laboratory (The Francis Crick Institute) and Faculty of Infectious and Tropical Diseases (London School of Hygiene & Tropical Medicine):

Rimants Zogota, Linda Kinena, Chrislaine Withers-Martinez, Michael J. Blackman, Raitis Bobrovs, Teodors Pantelejevs, Iveta Kanepe-Lapsa, Vita Ozola, Kristaps Jaudzems, Edgars Suna
Aigars Jirgensons (2019) Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D, European Journal of Medicinal Chemistry, 163 (1), 344-352, DOI: 10.1016/j.ejmech.2018.11.068

19.12.2018._Eur.J.Med.Chem

 

ENABLE project video

Latvian Institute of Organic Synthesis is a member of the ENABLE consortium since 2014.

The ENABLE consortium is working to advance the development of promising new antibiotic compounds targeting Gram-negative bacteria such as Escherichia coli. The goal of the project is to develop attractive antimicrobial candidates for extensive preclinical studies and First-in-Human clinical trials, bringing new antibiotics to treat Gram-negative infections one step closer to patients.

The video introduces ENABLE, its drug discovery platform, expert network and explains how to submit an Expression of Interest (EoI).

 

Learn more about ENABLE project

New commentary article from E. Liepinsh and M. Dambrova: Letter to the Editor: “Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris”

The Journal of Clinical Endocrinology & Metabolism (IF 2017: 5.789) published a letter to editor from E. Liepinsh and prof. M. Dambrova.

Liepins_Dambrova

Edgars Liepinsh & Maija Dambrova (2018) Letter to the Editor: “Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris”, The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 11, Pages 4037–4038, DOI: 10.1210/jc.2018-01408