News

The 3rd project Alliance4Life meeting

The 3rd meeting of Alliance4Life  consortium was held in University of Zagreb, School of Medicine in Croatia from 3 to 5 December 2018.

Alliance4Life is consortium of ten research institutions from nine Central and Eastern European countries and it aims at addressing the existing gap in health research and innovation performance between EU15 and EU13 countries.

Three meeting days covered a full agenda with focus group discussions dedicated to the development of best practices, strategies, and policy recommendations for the future operation of the Alliance.

The interested participants attended two training sessions – Modern Trends in HR, and How to Prepare a Successful MSCA-IF Proposal. Also Mr. Telemachou from the European Commission gave a presentation about Sharing Excellence in Horizon Europe.

3rd_A4L_meeting_Zagreb

Just released: Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D

The European Journal of Medicinal Chemistry (IF 2017: 4.816) published a research paper from Latvian Institute of Organic Synthesis, Malaria Biochemistry Laboratory (The Francis Crick Institute) and Faculty of Infectious and Tropical Diseases (London School of Hygiene & Tropical Medicine):

Rimants Zogota, Linda Kinena, Chrislaine Withers-Martinez, Michael J. Blackman, Raitis Bobrovs, Teodors Pantelejevs, Iveta Kanepe-Lapsa, Vita Ozola, Kristaps Jaudzems, Edgars Suna
Aigars Jirgensons (2019) Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D, European Journal of Medicinal Chemistry, 163 (1), 344-352, DOI: 10.1016/j.ejmech.2018.11.068

19.12.2018._Eur.J.Med.Chem

 

ENABLE project video

Latvian Institute of Organic Synthesis is a member of the ENABLE consortium since 2014.

The ENABLE consortium is working to advance the development of promising new antibiotic compounds targeting Gram-negative bacteria such as Escherichia coli. The goal of the project is to develop attractive antimicrobial candidates for extensive preclinical studies and First-in-Human clinical trials, bringing new antibiotics to treat Gram-negative infections one step closer to patients.

The video introduces ENABLE, its drug discovery platform, expert network and explains how to submit an Expression of Interest (EoI).

 

Learn more about ENABLE project

New commentary article from E. Liepinsh and M. Dambrova: Letter to the Editor: “Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris”

The Journal of Clinical Endocrinology & Metabolism (IF 2017: 5.789) published a letter to editor from E. Liepinsh and prof. M. Dambrova.

Liepins_Dambrova

Edgars Liepinsh & Maija Dambrova (2018) Letter to the Editor: “Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris”, The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 11, Pages 4037–4038, DOI: 10.1210/jc.2018-01408

 

New article from prof. Jirgensons group: Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives

The Journal of Enzyme Inhibition and Medicinal Chemistry (IF 2017: 3.638) published a research paper from prof. Jirgensons group in collaboration with Food and Drug Department, University of Parma and National Research Council, Institute of Biophysics, Pisa:

Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, Gabriele Costantino, Aigars Jirgensons & Andrea Mozzarelli (2018) Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives, Journal of Enzyme Inhibition and Medicinal Chemistry, 33:1, 1343-1351, DOI: 0.1080/14756366.2018.1504040

10.10.2018_J.Enz

Research was supported by the MSCA-ITN-2014-ETN project INTEGRATE under Grant 642620.

Journal of Enzyme Inhibition and Medicinal Chemistry Impact Factor: 3.638 (IF 2017).

LIOS joined the EURAXESS Latvia network

euraxcess-2

Latvian Institute of Organic Synthesis has become a member of EURAXESS Latvia network in  September 2018.

The main task of EUROAXESS Latvia network is to provide information and consult researchers on possibilities of scientific career in Latvia as well as practically support researchers and their families to plan and organize their move to Latvia.

EURAXESS is a pan-European initiative launched by the European Commission with the aim to support mobile researchers and their family members on their relocation to another country.

Alliance4Life project meeting

On June 18–20 (2018) a second meeting of the Alliance4Life consortium was held in beautiful Smolenice castle (Slovakia).

Alliance4Life is consortium of ten research institutions from nine Central and Eastern European countries and it aims at addressing the existing gap in health research and innovation performance between EU15 and EU13 countries.

Information about the progress in each research group can be found in the 1st Newsletter of the project: Newsletter June 2018