INNOCENT project meeting in Riga

M-era.Net project INNOCENT 3rd Partner meeting took place at Latvian Institute of Organic Synthesis from Monday, April 15 – Tuesday, April 16, 2019.

The objective of this meeting was to discuss the progress and detailed plans of individual research groups for the final 6 month period and to discuss possibility of project extension.


Learn more about INNOCENT project!

Great collaboration within the COST action

Collaboration within the COST action CA16112 “Personalized Nutrition in aging society: redox control of major age-related diseases”  has resulted in the publication in the open access journal Nutrients (IF 4.196):

Tess De Bruyne, Bieke Steenput, Lynn Roth , Guido R. Y. De Meyer, Claudia Nunes dos Santos, Kateřina Valentová, Maija Dambrova, Nina Hermans.
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism.Nutrients 2019, 11(3), 578; doi:10.3390/nu11030578


INNOCENT project findings in the design of nanoparticle delivery materials

Journal Pharmaceutics (IF = 3.746) published a research paper from EuroNanoMed2 project “Innovative nanopharmaceuticals: targeting breast cancer stem cells by a novel combination of epigenetic and anticancer drugs with gene therapy” (INNOCENT):

Martins Rucins, Pavels Dimitrijevs, Klavs Pajuste, Oksana Petrichenko, Ludmila Jackevica, Anita Gulbe, Signe Kibilda, Krisjanis Smits, Mara Plotniece, Dace Tirzite, Karlis Pajuste, Arkadij Sobolev, Janis Liepins, Ilona Domracheva, Aiva Plotniece. Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines. Pharmaceutics 2019, 11(3), 115.


THIOREDIN project discovers the novel derivatives of dithiodiglycolic acid as TrxR1 inhibitors

The Journal of Enzyme Inhibition and Medicinal Chemistry (IF 2017: 3.638) published a research paper from ERA.Net RUS Plus Call 2017 “HEALTH” project “Development of thioredoxin reductase inhibitors towards new anticancer agents“:

Olga Bakulina,Anton Bannykh, Mirna Jovanović, Ilona Domračeva, Ana Podolski-Renić, Raivis Žalubovskis, Milica Pešić, Dmitry Dar’in, Mikhail Krasavin.
Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34(1), pp. 665-671, DOI: 10.1080/14756366.2019.1575372


New article in the field of OLED Semiconductors

An article from the partnership of LIOS and Kaunas University of Technology researchers is published in Chemistry-A European Journal (Impact Factor: 5.16 (2017)):

Brigita Vigante, Karolis Leitonas, Dmytro Volyniuk, Viktorija Andruleviciene, Jurate Simokaitiene, Anna Ivanova, Audrius Bucinskas, Juozas V. Grazulevicius, Pavel Arsenyan.

Synthesis of Linear and V‐Shaped Carbazolyl‐Substituted Pyridine‐3,5‐dicarbonitriles Exhibiting Efficient Bipolar Charge Transport and E‐Type Fluorescence Chem. Eur. J. 2018, DOI: 10.1002/chem.201805323


This research was supported by the project of scientific co-operation program between Latvia, Lithuania and Taiwan “Synthesis and studies of high-triplet-energy materials for blue OLEDs
(grant No. TAP-LLT-2/2017, No LV-LT-TW/2018/11)


New research: Design of organic luminescent molecules

Design of organic luminescent molecules is a new research direction at LIOS funded by Taiwan–Lithuania–Latvia Tripartite Cooperation Fund, project “New materials and technologies for very-high color rendering and high sunlight spectrum resemblance OLED lighting sources”.

One of the project results is published in the open access journal RSC Advances (Impact factor: 2.936):

Aggregation induced emission by pyridinium–pyridinium interactions
RSC Adv., 2019, 9, 460-465, DOI: 10.1039/C8RA08771G