Just released article on the synthesis of fluorocyclopropanes using fluoromethylsulfonium reagent

The research on the synthesis of fluorocyclopropanes using fluoromethylsulfonium reagent from LIOS has been published in the ACS journal “Organic Letters” (IF 6.555):

Renate Melngaile, Arturs Sperga, Kim K. Baldridge, Janis Veliks.
Diastereoselective Monofluorocyclopropanation Using Fluoromethylsulfonium Salts.
Org. Lett. 2019, DOI: 10.1021/acs.orglett.9b02867


Recent publication in the field of process chemistry

Dr. Viesturs Lusis group (LIOS) study on the synthesis of impurities as reference compounds for HPLC analysis, produced in Pazopanib synthesis is published in the ACS journal “Organic Process Research and Development” (IF 3.327):

Svetlana Terentjeva, Dzintra Muceniece, Viesturs Lusis.
Process-Related Impurities of Pazopanib.
Org. Process Res. Dev. 2019, DOI: 10.1021/acs.oprd.9b00117


New publication in the field of enantioselective catalysis

Research in the field of enantioselective catalysis performed by researchers from LIOS (Dr. Gints Šmits) and Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL) has been published in the journal Organometallics (IF=4.1, 2018):

Coralie Duchemin, Gints Smits, Nicolai Cramer
RhI, IrIII ,and CoIII Complexes with Atropchiral Biaryl Cyclopentadienyl Ligands: Syntheses, Structures, and Catalytic Activities,
DOI: 10.1021/acs.organomet.9b00365


Sulfocoumarins as a promising class of cancer-associated carbonic anhydrase inhibitors

Research of Prof. R. Žalubovskis group (LIOS) and scientists from Serbia (Institute for Biological Research “Sinisa Stankovic”, State University of Novi ) has been published in European Journal of Pharmaceutical Sciences (IF 3.532, 2018) on sulfocoumarins as a promising class of cancer-associated carbonic anhydrase inhibitors:

Ana Podolski-Renić,Jelena Dinić,Tijana Stanković, Mirna Jovanović, Amra Ramović, Aleksandrs Pustenko, Raivis Žalubovskisc, Milica Pešić.
Sulfocoumarins, specific carbonic anhydrase IX and XII inhibitors, interact with cancer multidrug resistant phenotype through pH regulation and reverse P-glycoprotein mediated resistance.


New approach for peptide functionalization

Dr. Pavel Arsenyan group showed a new approach for peptide functionalization through the generation of selenocysteine electrophile. This method is published in the European Journal of Organic Chemistry (IF 3.029):

Pavel Arsenyan, Sindija Lapcinska, Anna Ivanova, Jelena Vasiljeva.
Peptide Functionalization Through the Generation of Selenocysteine Electrophile.
Eur. J. Org. Chem., 2019, DOI: 10.1002/ejoc.201900907.


This article is devoted to the memory of Professor Edvards Liepinsh (1944–2019).

New article in the field of OLEDs

The joint article from Pavel Arsenyan (LIOS), Alla Petrenko (LIOS), Karolis Leitonas, Dmytro Volyniuk, Jurate Simokaitiene, Tomas Klinavičius, Eigirdas Skuodis, Jiun-Haw Lee, Juozas Vidas Gražulevičius on new iridium(III) complexes containing a 2-(benzo[b]selenophen-2-yl)pyridine ligand has been published in the journal “Inorganic Chemistry” (Impact Factor 4.85).

Synthesis and Performance in OLEDs of Selenium-Containing Phosphorescent Emitters with Red Emission Color Deeper Than the Corresponding NTSC Standard.

Inorg. Chem. 2019, 58, 15, 10174-10183. DOI: 10.1021/acs.inorgchem.9b01283

Released new article on selenopheno[2,3-f]coumarins

Dr. Pavel Arsenyan group has published an arlicle in the field of medicinal chemistry:


The Impact factor of the New Journal of Chemistry is 3.069 (2018)


Round Table Discussion For Better Science in Latvia

In June 10, the Latvian Institute of Organic Synthesis (LIOS), as a member of Alliance4Life, organized a national round table discussion for Latvian policymakers and stakeholders in Jūrmala. The aim of the event was to present the Alliance4Life project outputs and discuss how the findings of the Alliance4Life community could be implemented to improve the Latvian scientific environment.

The Latvian round table was attended by representatives of the Latvian Ministry of Education and Science, the State Education Development Agency, the Ministry of Economics, the Association of the Latvian Chemical and Pharmaceutical Industry, and the Association of Latvian Young Scientists.

In addition, representatives of CEITEC Masaryk University (Czech Republic) took part in this even.

To read the press release, click HERE



Lear more about project Alliance4Life in web page!

4th Alliance4Life Meeting in Latvia

Almost 100 representatives from ten research centres and universities from nine Central and Eastern European (CEE) countries met for the fourth time at the Alliance4Life meeting in early June. These partners form a unique community of institutions in the life sciences and medical fields that is unparalleled in the region. The focus of the meeting was to share best practices and receive training from internal and external experts, as well as discuss the future of the alliance.

The Latvian seaside resort of Jūrmala was the centre of lively discussions held over several days, aimed at sharing ideas for achieving qualitative changes in the management of institutions, thus creating more favourable conditions for high-quality research in life sciences. The Latvian Institute of Organic Synthesis (LIOS), one of the Alliance4life members, was the host of the event.

Both experts from the member institutions and invited lecturers from outside of the alliance were involved in sharing best practices through lectures and training sessions in the plenary sessions. The agenda of the Steering Committee meetings and the Strategy Board focused on planning the alliance’s future strategy and activities, particularly from 2020. Several decisions were made, such as achieving greater involvement of researchers in project-based collaboration, building greater capacity for shaping European research policy, and strengthening collaborations with other EU networks. A draft of a White Paper with specific recommendations for policymakers at the national and European levels was also discussed.

The alliance was created as a joint project that received support from the Horizon 2020 European Framework Program for Research and Innovation. “It is certainly positive that the alliance, thanks to its intensive joint work, has turned into a real association over the last two years. This is evidenced by the draft Memorandum of Understanding that is foreseen to be signed at the next meeting in Vilnius in October, thus establishing the Alliance4Life as a permanent structure,” explained Zlatuše Novotná, Head of Strategic Partnerships and International Relations at CEITEC MU and Alliance4Life Coordinator.

 “We have succeeded in creating a platform based on the discussion of focus groups working on the most pressing topics relevant to every CEE research institution –  scientific strategy and research evaluation, grants, institutional management, technology transfer, human resources and training, and PR and communication,” said Jiří Nantl, Director of CEITEC MU.

10-12June_2019_Liga Lejiņa, State Secretary of the Ministry of Education and Science of the Republic of Latvia
Opening speech by Liga Lejiņa, State Secretary of the Ministry of Education and Science, Republic of Latvia

Opening speech by Osvalds Pugovičs, Director of LIOS
Opening speech by Osvalds Pugovičs, Director of LIOS

10-12June_2019_Opening speech by Jiří Nantl, Chair of Strategy Board and Director of CEITEC Masaryk UniversityOpening speech by Jiří Nantl, Chair of Strategy Board and Director of CEITEC Masaryk University

10-12June_2019_Plenary session during J. Nantl's speechPlenary session

For more information please visit

All4Life Alliance4Life research centres and universities have been working together since 2018 to improve their functions as a whole, including the internal cultures of their scientific worksites, management quality, and personnel policy rules. In the Alliance4Life, Latvia is represented by LIOS.