Physical organic chemistry equipment

Analytical chemistry support

  • 400 MHz NMR system (autosampler, Bruker Avance Neo, cryoprobe Prodigy)
  • 400 MHz NMR system (solution (BB) and solid state probes, Varian Mercury)
  • 300 MHz NMR system (open access spectrometer, autosampler, Bruker Fourier)
  • powder (Rigaku) and single crystal (Bruker) X-ray spectrometers
  • GC-based microanalysis system (Carlo Erba)
  • Synapt GII q-ToF HRMS system coupled to Acquity LC (Waters)
  • FT-IR spectrometer with IR spectra library (Shimadzu)
  • polarimeter (Rudolph Research Analytical)
  • analytical HPLC systems with UV, PDA, fluorescence and light scattering detectors; diverse set of normal phase, reversed phase and chiral stationary phase columns
  • GC/FID system equipped with diverse set of capillary GC columns including columns for chiral separation (Agilent Technologies)
  • Bruker BioSpin X-band EPR spectrometer

Biophysical chemistry methods

  • 800 MHz NMR system (solution state HCN probe, solid state probe, Bruker Avance)
  • 600 MHz NMR system (solution state HCN probe, cryoprobe, Bruker Avance Neo)
  • Surface Plasmon Resonance spectrometer (Biacore)
  • isothermal titration calorimeter (GE Healthcare)
  • fully equipped biochemistry laboratory for protein expression (in E. coli and cell-free)

Chemo- and bioinformatics resources

  • Shroedinger, Gaussian and PyMol softwares for computer assisted drug design
  • 120 CPU/20 GPU Computer cluster

Bioanalytical support resources

  • Quattro Micro tandem mass-spectrometer with Acquity UPLC front end (Waters)
  • Xevo TQ-S tandem mass-spectrometer with H-class Acquity UPLC front end (Waters)
  • Micro TQS tandem mass-spectrometer with H-class Acquity UPLC front end (Waters)
  • sample preparation equipment for metabolic stability, PPB etc. studies