Continuing studies of cobalt-catalyzed C(sp2)–H carbonylation reactions Liene Grigorjeva et al. (Organic Synthesis Methodology group) have reported an efficient protocol for the synthesis of 1,2-dihydroisoquinolinone derivatives based on an inexpensive cobalt(II) salt catalyst. This method is published in the high-impact ACS journal Organic Letters (IF=6.555).
In this approach carbonylation of amino acids was accomplished using picolinamide as a traceless directing group, CO (1 atm) as the carbonyl source, and Co(dpm)2 as the catalyst. The authors demonstrated that a broad range of phenylalanine derivatives bearing diverse functional groups were tolerated. The method can be successfully applied for the C(sp2)–H carbonylation of short peptides as well.
Lukasevics, L., Cizikovs, A., Grigorjeva, L.*
Cobalt-Catalyzed C(sp2)–H Carbonylation of Amino Acids Using Picolinamide as a Traceless Directing Group.
Org. Lett., 2021. DOI: 10.1021/acs.orglett.1c00660
This research is funded by the Latvian Council of Science, project [Cobalt catalyzed C–H bond functionalization], project no. lzp-2019/1-0220.
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