Organic Synthesis Methodology group



Prof. Aigars Jirgensons
Head of the Team
Phone: (+371) 67014948
Laboratory website:

The organic Synthesis Methodology group develops synthetic methods to support drug discovery and process chemistry projects.

Selected recent publications

  1. Charlton, M.H.; Aleksis, R.;  Saint-Leger, A.;  Gupta, A.;  Loza, E.;  Ribas De Pouplana, L.;  Kaula, I.; Gustina, D. ; Madre, M. ; Lola, D.;  Jaudzems, K.;  Edmund, G.; Randall, C.P. ; Kime, L.; O’Neill, A.J.;  Goessens, W.;  Jirgensons, A.;  Finn, P.W. N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors ACS Med. Chem. Lett. 2018, 9(2), 84-88.
  2. Skvorcova, M; Jirgensons, A. Amide-Group-Directed Protonolysis of Cyclopropane: An Approach to 2,2-Disubstituted Pyrrolidines Org.Lett. 2017, 19 (10), 2478–2481.
  3. Petrova, E; Rasiņa, D;  Jirgensons, A. N-Sulfonylcarboxamide as an Oxidizing Directing Group for Ruthenium-Catalyzed C–H Activation/Annulation. Eur. J. Org. Chem. 2017, (13), 1773-1779.
  4. Skvorcova, M; Jirgensons, A. Intramolecular cyclopropylmethylation via non-classical carbocations. Org. Biomol. Chem., 2017, 15, 6909-6912.
  5. Rasina, D.; Otikovs, M.; Leitans, J; . Recacha, R.; Borysov, O. V.; Kanepe-Lapsa, I.; Domraceva, I.; Pantelejevs, T.; Tars, K.; Blackman, M. J.; Jaudzems, K.; Jirgensons, A. Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV. J. Med. Chem. 2016, 59, 374–387.