Laboratory of Physical Organic Chemistry

Alons Lends
Head of Laboratory
The main task of the Laboratory of Physical Organic Chemistry is to provide analytical services at the institute. The laboratory combines an array of physical chemistry techniques such as nuclear magnetic resonance (NMR) spectroscopy, masspectrometry, X-ray diffraction, electron paramagnetic resonance (EPR), infrared spectroscopy as well as electrochemical methods to perform identification and characterization of synthetic compounds. The Laboratory of Physical Organic Chemistry also performs studies of the molecular structure and its relationships to chemical reactivity, (bio)physical properties and biological activity of organic compounds. Research activities include structural studies of small molecules by NMR, masspectrometry and X-ray diffraction, structural studies of biological macromolecules (proteins and DNA) by NMR, protein-small molecule binding studies by NMR, SPR and ITC, pharmacokinetic and metabolic studies by masspectrometry, mechanistic studies of redox reactions and electrochemical synthesis as well as studies of free radicals in animal tissues by EPR etc.
Recent publications
  • Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients
    K. Krūkle-Bērziņa, A. Lends, A. Boguszewska-Czubara
    ACS Omega 2024, 9, 8, 8874–8884, DOI: 10.1021/acsomega.3c06745
  • Experimental Determination of the pKa Values of Clinically Relevant Aminoglycoside Antibiotics: Toward Establishing pKa─Activity Relationships
    R. Muhamadejevs, K. Haldimann, M. Gysin, D. Crich, K. Jaudzems, Sven N. Hobbie
    ACS Omega 2024, 9, 5, 5876-5887 , DOI: 10.1021/acsomega.3c09226
  • Halogen-bonded shape memory polymers
    H. Guo, R. Puttreddy, T. Salminen, A. Lends, K. Jaudzems, H. Zeng, A. Priimagi
    Nature Communications 2022, 13 (1), 7436, DOI: 10.1038/s41467-022-34962-7
  • Interactions between s100a9 and alpha-synuclein: insight from NMR spectroscopy
    Z .Toleikis, R. Bobrovs, A. Janoniene, A. Lends, M. Ziaunys, I. Baronaite, V. Petrauskas, K. Kitoka, V. Smirnovas, K. Jaudzems
    Int. J. Mol. Sci. 2022, 23 (12), 6781, DOI: 10.3390/ijms23126781
  • Residual Solvent Signal of CDCl3 as a qNMR Internal Standard for Application in Organic Chemistry Laboratory
    R. Muhamadejev , R. Melngaile , P. Paegle , I. Zibarte , M. Petrova , K. Jaudzems, J. Veliks
    J. Org. Chem. 2021, 86, 5, 3890–3896, DOI: 10.1021/acs.joc.0c02744