Biologically Active Compound Synthesis Laboratory




Dr. chem. Mārtiņš Katkevičs
Head of Laboratory
Phone: (+371) 67014814

The Laboratory is engaged in custom synthesis and process development on a contract research basis. Our specialties are new methodologies for heterocycles construction, copper catalysed reactions and synthesis of modified amino acid, sugars as well as nucleoside derivatives.

Recent publications

  1. Melnika I., Bringis K., M. Katkevics M.,Synthesis of N-methylcarbazoles from N-(2-iodoaryl)-N-methylanilines in the presence of potassium tert-butoxide and iron(II) bromide”, Chem. Heterocycl. Comp. 2013, 529-539.
  2. Krasikova V., Katkevics M.,”Preparation of benzoiosthiazolones from 2-bromobenzamides and sulfur under copper catalysis conditions”, Chem. Heterocycl. Comp. 2012, 1684-1690.
  3. Kukosha T., Trjufilkina N., S. Belyakov, Katkevics M., „Copper-Catalyzed Cross-Coupling of O-Alkyl Hydroxamates with Aryl Iodides”, Synthesis 2012, 44, 2413-2423.
  4. Kukosha T., Trjufilkina N., Katkevics M. „Synthesis of N-Alkoxyindol-2-ones by Copper-Catalyzed Intramolecular N-Arylation of Hydroxamates”, Synlett 2011, 2525-2528.
  5. Katkevics M., Kukosha T., Lukevics E. „Heterocycles from hydroxylamines and hydroxamic acids”, in „The chemistry of Hydroxylamines, Oximes and Hydroxamic Acids”, Vol 2, (Ed. Z. Rappoport and J. F. Liebman), John Wiley and Sons, Chichester 2011, pp 205-294.

Recent patents

  1. Nilson P.; Pelcman B.; Katkevics M.,. Bis Aromatic compounds in the treatment of inflammation. BRPI0816320 (A2) 24.03. 2015.
  2. Nilson P.; Pelcman B.; Katkevics M., Roenn R., Krog-Jensen C. Bis Aromatic compounds for use as LTC4 synthase inhibitors. US2013035358 (A1) 02.07. 2013
  3. Pelcman B, Olofsson K, Katkevics M, Ozola V, Suna E, Kalvins I, Trapencieris P, Katkevica D, Schaal W, Indoles useful in the treatment of inflammation. US 8097623 (B2), 17.01. 2012.
  4. Nilson P.; Pelcman B.; Katkevics M.; Suna E.; Popovs I. Bis Aromatic compounds for use as LTC4 synthase inhibitors. US2012035217  (A1) 09.02.2012
  5. Katkevics M.; Nilsson P.; Pelcman B. Bis-Aryl Compounds for use as Medicaments. EP2274280 (A2), 19.1, 2011.