Scientists discover synthetic approach toward enantiopure cyclic sulfinamides

Prof. Edgars Suna’s group  (Latvian Institute of Organic Synthesis) has elaborated a new synthetic approach to obtain densely substituted enantiopure cyclic sulfinamides. The method has been published in the journal Organic Letters (IF=6.005).

This synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective S_N2′ cyclization/tert-Bu cleavage sequence. Researchers demonstrated diastereospecific transformation of the obtained scaffold into chiral S^VI derivatives such as sulfoximines and sulfonimidamides as well.