Project No. | LZP-2021/1-0595 |
|---|---|
Project coordinator | Latvian Institute of Organic Synthesis (LIOS)
|
Project manager | Dr. Igors Sokolovs (LIOS) |
Implementation period | 36 months (2022-2024) |
Total cost
| 299 999,70 EUR |
The scientific objective of this research project is the development of environmentally friendly, sustainable, and scalable synthetic methodologies for electrochemical production of stabilized organo-λ3-bromanes using divided electrochemical cell and electrochemical flow reactor.
Successful implementation of the project will result in the development of an inexpensive, environmentally benign, and safe method for obtaining organo-λ3-bromanes. This will enable further investigation of the propertie of these compounds and their application in organic chemistry as well as development of biologically active substances and smart materials.
The developed method is intended to be transferred to a continuous flow electrochemical cell, which will, if necessary, enable the industrial production of organo- λ3-bromanes.
Project Progress
The following research activities were carried out during the reporting period:
- Optimization studies for the electrochemical oxidation of ethyl 2-bromobenzoate (WP1);
- Synthesis of aryl bromides with different ortho-chelating groups (WP1).
Publication date 05.04.2022
The following research activities were carried out during the reporting period:
- Electrochemical oxidation of different aryl bromides and reaction product identification (WP1);
- The development of method for electrochemical generation of dimeric λ3-bromane (WP1).
Publication date 05.07.2022
The following research activities were carried out during the reporting period:
- Synthesis of a series of bromine(III) congeners from dimeric λ3-bromane (WP1);
- Investigation of electrochemical properties of prepared λ3-bromanes (WP1);
- Preliminary studies of chemical properties of dimeric λ3-bromane (WP1).
Publication date 04.10.2022
The following research activities were carried out during the reporting period:
- The development of method for photoinduced Minisci-type heteroarylation with dimeric λ3-bromane (WP1);
- The development of method for late-stage oxidative functionalization of complex natural products and pharmaceuticals with dimeric λ3-bromane (WP1).
Publication date 03.01.2023
The following research activities were carried out during the reporting period:
- Initial investigation of photoinduced Minisci-type heteroarylation reaction mechanism (WP1);
- Writing and submitting a publication manuscript on the Electrochemical Synthesis of Dimeric λ3-Bromane (WP3).
Publication date 04.04.2023
The following research activities were carried out during the reporting period:
- Optimization studies for the Minisci-type borylation (WP1);
- Synthesis of aryl bromides with longer conjugated bond system (WP1);
- Participation and poster presentation at the 7th International Conference on Hypervalent Iodine Chemistry (ICHIC 7) conference (Igors Sokolovs, WP3).
Publication date 04.07.2023