Structure determination of amyloid oligomers, the pathogenic species in Alzheimeŕs disease using fast MAS NMR and microfluidics

Alzheimer’s disease is a progressive neurodegenerative disorder affecting mainly the elderly population. It is characterised by the accumulation of amyloid beta and tau protein aggregates in neuronal cells. Despite their confirmed neurotoxicity, these protein oligomers have not been structurally characterised in detail. The scope of this project is to determine the structure and interaction of amyloid beta and tau oligomers using cutting-edge technologies.

Project results will provide fundamental knowledge in protein misfolding and aggregation in Alzheimer’s disease, opening new possibilities for the design of novel treatment strategies.