Published new synthetic methodology for electrophilic fluorination of heterocycles

Continuing studies of electrophilic fluorination of heterocycles, Dr. Nadia Pikun with her colleagues from the Laboratory of Membrane Active Compounds and β-diketones has elaborated  a new approach to the synthesis of methyl 2-(fluoromethyl)-5-nitro-6-arylnicotinates by the fluorination of 3-fluoro-2-methyl-5-nitro-3,6-dihydropyridines or 1,2-dihydropyridines with Selectfluor®.

The research is published in the Molecules (IF=3.267, 2019):

Pikun, N.V.;* Sobolev A., Plotniece A., Rucins M., Vigante B., Petrova M., Muhamadejev R., Pajuste K.,  Shermolovich Y.G.
Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor®.
Molecules 2020, 25(14), 3143; doi: 10.3390/molecules25143143

Studies were financially supported by the PostDoc project Nr.