An attractive methodology for obtaining 1-aminoisoquinoline derivatives

Continuing studies of cobalt-catalyzed C–H bond functionalization reactions Liene Grigorjeva, PhD et al. (Organic Synthesis Methodology group) have reported an attractive methodology for obtaining 1-aminoisoquinoline derivatives. This research is published in the high-impact journal Chemical Communications (IF = 6.065).

LIOS researchers have reported the cobalt-catalyzed, picolinamide-directed C-H bond imination protocol of phenylalanine derivatives using isocyanides and Co(dpm)2 catalyst. They have shown that a wide range of functional groups were tolerated under the reaction conditions and yielded imines in high yields. Further, the obtained imine products can be easily transformed to 1-aminoisoquinoline derivatives providing a convenient alternative to already existing synthetic methods.