An attractive methodology for obtaining 1-aminoisoquinoline derivatives

Continuing studies of cobalt-catalyzed C–H bond functionalization reactions Liene Grigorjeva, PhD et al. (Organic Synthesis Methodology group) have reported an attractive methodology for obtaining 1-aminoisoquinoline derivatives. This research is published in the high-impact journal Chemical Communications (IF = 6.065).

LIOS researchers have reported the cobalt-catalyzed, picolinamide-directed C-H bond imination protocol of phenylalanine derivatives using isocyanides and Co(dpm)2 catalyst. They have shown that a wide range of functional groups were tolerated under the reaction conditions and yielded imines in high yields. Further, the obtained imine products can be easily transformed to 1-aminoisoquinoline derivatives providing a convenient alternative to already existing synthetic methods.

Read the article:

Lukasevics, L., Cizikovs, A., Grigorjeva, L.*
Cobalt-catalyzed C(sp2)–H bond imination of phenylalanine derivatives.
Chem. Commun., 2022. DOI: 10.1039/D2CC02334B