Continuing studies of cobalt-catalyzed C–H bond functionalization reactions Liene Grigorjeva, PhD et al. (Organic Synthesis Methodology group) have reported an attractive methodology for obtaining 1-aminoisoquinoline derivatives. This research is published in the high-impact journal Chemical Communications (IF = 6.065).
LIOS researchers have reported the cobalt-catalyzed, picolinamide-directed C-H bond imination protocol of phenylalanine derivatives using isocyanides and Co(dpm)2 catalyst. They have shown that a wide range of functional groups were tolerated under the reaction conditions and yielded imines in high yields. Further, the obtained imine products can be easily transformed to 1-aminoisoquinoline derivatives providing a convenient alternative to already existing synthetic methods.
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Lukasevics, L., Cizikovs, A., Grigorjeva, L.*
Cobalt-catalyzed C(sp2)–H bond imination of phenylalanine derivatives.
Chem. Commun., 2022. DOI: 10.1039/D2CC02334B