Organic Chemistry

Development of new synthetic methodologies

  • Late transition metal-catalyzed reactions
  • C–H functionalization based on Cu catalysis and hypervalent I(III) chemistry
  • Lewis acid catalyzed allylic substitution
  • Reactions involving carbenium ion intermediates
  • Diastereoselective synthesis
  • Development of novel routes to unnatural amino alcohols and amino acids
  • Novel protecting groups for sulfonamide and hydroxamic acid
  • Chemistry of selenium
  • Total synthesis and semi-synthesis of natural products

    1. Semi-synthesis of libiguin A
      • Grigorjeva, L.; Liepinsh, E.; Razafimahefa, S.; Yahorau, A.; Yahorava, S.; Rasoanaivo, P.; Jirgensons, A.; Wikberg, J. J. Org. Chem. 2014, 79, 4148. 10.1021/jo500318w
    2. Total synthesis of diazonamide A
      • Mutule, I.; Joo, B.; Medne, Z.; Kalnins, T.; Vedejs, E.; Suna, E. J. Org. Chem. 2015, 80, 3058.10.1021/jo5029419
    3. Total synthesis of barmumycin, limazepine E and 8-deoxypumiliotoxin
    4. Total synthesis of vidolicine

    Materials science

    1. Design, synthesis and characterisation of self-assembling compounds in the development of nanoparticles as delivery systems
      • Petrichenko, O.; Rucins, M.; Vezane, A.; Timofejeva, I.; Sobolev, A.; Cekavicus, B.; Pajuste, K.; Plotniece, M.; Gosteva, M.; Kozlovska, T.; Plotniece, A. Chem. Phys. Lipids 2015, 191, 25. 10.1016/j.chemphyslip.2015.08.005
      • Pajuste, K.; Hyvönen, Z.; Petrichenko, O.; Kaldre, D.; Rucins, M.; Cekavicus, B.; Ose, V.; Skrivele, B.; Gosteva, M.; Morin-Picardat, E.; Plotniece, M.; Sobolev, A.; Duburs, G.; Ruponen, M.; Plotniece, A. New J. Chem. 2013, 37, 3062. 10.1039/C3NJ00272A
      • Rucins M.; Petricenko O.; Pajuste K.; Plotniece M.; Pajuste K.; Gosteva M.; Cekavicus B.; Sobolev A.; Plotniece A. Adv. Materials Res. 2013, 787, 157
    2. Preparation and characterisation of magnetic nanoparticles and magnetic liposomes
      • Petrichenko O.; Plotniece A.; Pajuste K.; Ose, V.; Cēbers, A.Chem Heterocycl. Comp. 2015, 51, 672. 10.1007/s10593-015-1755-9
      • Petričenko O.; Ērglis K.; Cēbers A.; Plotniece A.; Pajuste K.; Béalle G.; Ménager Ch.; Dubois E.; Perzynski R. Eur. Phys. J. E 2013, 36(9), 10.1140/epje/i2013-13009-0
    3. Design of fluorescent compounds as polychromic emission probes (including near infrared region)
      • Bekere L.; Gachet D.; Lokshin V.; Marine W.; Khodorkovsky V. Beil. J Org. Chem. 2013, 9, 1311. 10.3762/bjoc.9.147
      • Rivoal M.; Bekere L.; Gachet D.; Lokshin V.; Marine W.; Khodorkovsky V. Tetrahedron 2013, 69, 3302. 10.1016/j.tet.2013.02.007
    4. Design of magnetic iron oxide-based nanoparticles with immobilized biologically active compounds for biomedical application
      • Zablotskaya, A.; Segal, I.; Popelis, Y.; Mishnev, A.; Maiorov, M.; Zablotsky, D.; Blums, E.; Nikolajeva, V.; Eze, D. Appl. Organomet. Chem. 2015, 29, 376. 10.1002/aoc.3302
      • Zablotskaya, A.; Segal, I.; Mishnev, A.; Maiorov, M.; Blums, E.; Shestakova, I.; Domracheva, I. Appl. Organomet. Chem. 2013, 27, 716. 10.1002/aoc.3049