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Dr. chem. Vitālijs Romanovs
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Scientific interests:
Chemistry of organilsilyl(germyl)furans, organilsilyl(germyl)thiophenes and organilsilyl(germyl)nitrogen–containing heterocycles, structure, biological activity, structure-activity relationships, hypercoordination.
Chemistry of β-lactam and γ-lactam derivatives and the investigation of their structure activity relationships.
Improvement of pharmacological properties of nitrogen containing biologically active compounds by their chemical modification (synthesis of organosilicon and “dual action” prodrugs, synthesis and investigation of mixed ligand organometallic complexes as antitumour and antimicrobial agents). Design, synthesis, physico-chemical and biological study of magnetic iron oxide based nanoparticles with immobilized biologically active compounds for biomedical application
Recent publications
- *Romanovs, V.; Spura, J.; *Jouikov, V. Synthesis and electrochemical study of 1,1′ -thienyl – substituted fused bis-germatranes with a core 5c-6e hyperbond. Synthesis. 2018.
- Romanovs, V.; Sidorkin, V.; Belogolova, E.; *Jouikov, V. Radical cations of phenyl silatrane. Dalton Trans. 2017, 46 (27), 8849-8854.
- Wang, Y.; Romanovs V.; Spura J.; Ignatoviča L.; Roisnel T.; *Jouikov V. Anisyl-, aminophenyl-, and naphthylmethylsilatranes revisited. Heterocycl. Compd. 2016, 52 (8), 546-550.
- *Ignatovich L.; Romanovs V.; Muravenko V.; Sleiksha I.; Popelis Y.; Shestakova I. Synthesis and Cytotoxic Activity of 1-{3-[1-(5-Organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and Some Trimethylgermyl Analogues.. Chem.-Eur. J. 2014, 20, 12786-12788.
- *Ignatovich L.; Starkova O.; Romanovs V.; Sleiksha I.; Shestakova I.; Popelis J.; Lukevics E. Novel trialkylsilyl(germyl)-substituted thienyl- and furylbenzimidazoles and their N-substituted derivatives – Synthesis, structure and cytotoxic activity. C. R. Chim. 2013, 16 (6), 621-627.