Researcher group from Latvian Institute of Organic Synthesis have investigated the molecular mechanisms of cellular insulin resistance.
They discovered that long-chain acylcarnitines decrease phosphorylation of insulin receptor and protein kinase B, thus limiting the cellular response to insulin.
This research is published in the International Journal of Molecular Sciences (IF = 4.56).
Read the article:
Vilks, K.*; Videja, M.; Makrecka-Kuka, M.; Katkevics, M.; Sevostjanovs, E.; Grandane, A.; Dambrova, M.; Liepinsh, E.
Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.
Int. J. Mol. Sci. 2021, 22, 6470. DOI: 10.3390/ijms22126470
This study was supported by a student grant from the Latvian Institute of Organic Synthesis IG-2017-03 and the Latvian Council of Science, project TRILYSOX, grant No. LZP-2018/1-0082.