Researchers at LIOS find a simple and convenient method for the synthesis of monofluoromethyl moiety containing molecules

Researchers at the Organic Synthesis Laboratory (LIOS) have developed a direct oxy-monofluoromethylation of a  wide range of olefinic substrates including biologically relevant molecules.

For the first time, Jānis Veliks et al. have presented a method where a visible-light copper(I)-photoredox catalysis in combination with easily accessible iodine(III) reagent containing monofluoroacetoxy ligands serves as a  powerful source of monofluoromethyl(CH2F)  radical.

The mild reaction conditions,  operational simplicity,  and broad scope of this methodology provide an easy approach towards monofluoromethyl containing molecules for further applications in medicinal chemistry and drug discovery.

The methodology has been published in the journal Angewandte Chemie (IF= 16.823).

Read the article:

Ramkumar, N., Baumane, L., Zacs, Dz., Veliks, J.*
Merging Copper(I)-photoredox Catalysis and Iodine(III) Chemistry for the Oxy-monofluoromethylation of Alkenes.
Angew. Chem., Int. Ed. 2023. DOI: 10.1002/anie.202219027