| Acronyme |
TENTACLES |
| Call |
The 10 Joint Call for the ERA-NET EuroNanoMed-III |
| Implementation period |
01.02.2020. – 31.01.2023. |
| Project coordinator |
Andrea Masotti, Ospedale Pediatrico Bambino Gesù-IRCCS
|
| Project partners |
Ospedale Pediatrico Bambino Gesù-IRCCS, Italy |
| Latvian Institute of Organic Synthesis, Latvia |
| FutureSynthesis. Sp. z o.o., Poland |
| Anses – Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail, France |
| Cancer Research Institute, Biomedical Research Center SAS, Slovakia |
| External collaborators |
Andrea Caporali, University of Edinburgh /BHF Centre For Cardiovascular Science The Queen’s Medical Research Institute, UK
Nicolas Cassinelli, nB nanoScale Biomagnetics, Spain |
| Project web page
|
https://www.tentacles-enm3.eu/ |
| Leader of Latvian team |
Dr. Arkadijs Sobolevs
|
| Total costs |
€ 914 400
|
| Costs for Latvian partner
|
€ 210 000
|
Summary
The development of novel therapeutically active wound dressings which provide the wound protection from ‘environmental’ effects as well as wound healing promotion has an advantageous potential for clinical applications. Nanotechnology-based materials incorporated into scaffolds allow the creation of nanocomposite smart materials with unique physicochemical and biological properties to promote regeneration. Our aim is to develop an innovative multifunctional nanogel that will integrate the protective and healing functions within one nanocomposite smart structure made by polymer-based nanohydrogel, iron oxide nanoparticles and targeted miRNAs.
The heating mediated by iron oxide nanoparticles will promote the induction of heat shock proteins (HSPs) involved in fibrogenesis and the production of extracellular matrix (ECM) production and transforming growth factor-β1 (TGF-β1), which is essential to fibrosis. Specific miRNA molecules will promote wound healing via expression/modulation of particular genes. The proposed innovation could revolutionize wound healing therapeutical strategy particularly for diabetic or long stay recovered patients.
