Project No. | lzp-2024/1-0309 |
Project coordinator | Latvian Institute of Organic Synthesis (LIOS) |
Project leader | Dr. Renāte Vaisgerberga (LIOS) |
Implementation period | 36 months (2025-2027) |
Total cost
| 300 000,00 EUR |
The aim of the project is to develop a novel fluorocarbene transfer reagent based on carbonyl or sulfonium salt precursors and explore its application in synthesis of new fluorinated building blocks. This will be achieved by following objectives:
1) Development and synthesis of novel fluorocarbene source – carboxylic acid fluorohalomethyl ester or fluorhalomethyl sulfonium salt as a synthetic equivalent of CHF synthon.
2) Improved synthetic methodology exploiting novel fluorocarbene source to obtain fluorinated small rings, X-H and C-C insertions, fluorocarbene cross-coupling products.
3) Validation of developed methodology on biologically significant drug molecules via introduction of fluorinated bioisosteres.
Expected outcomes: Novel and versatile monofluorocarbene source solving the long standing problem of non-existent fluorodiazomethane chemistry. Advantageous synthetic approach to access otherwise challenging fluorinated scaffolds in synthetic and medicinal chemistry fields.
