Exploring the Behavior of Self-assembling Styrylpyridinium and Its Aza-Analog Fluorescent Probes within Liposomes as Mimics of Biological Membranes (LipAgrStyrPro)

Project No.
lzp-2024/1-0364
Project coordinator; Project partner
Latvian Institute of Organic Synthesis (LIOS); Latvian Biomedical Research and Study Centre
Project leader
Dr. Aiva Plotniece (LIOS)
Implementation period
36 months (2025-2027)
Total cost
300 000,00 EUR

The aim of LipAgrStyrPro project is elaboration and studies of small molecular self-assembling fluorescent probes based on styrylpyridinium core and their aza-analogues for monitoring of liposomal traffic and biomembrane imaging.

We expect to elaborate dyes in which structural changes aim at tackling problems of existing fluorescent probes like evaluating long-term safety and toxicity, solving solubility issues, broadening the wavelength range and enhancing photostability.

For the first time, the interaction of dyes with lipid monolayers and elaboration of delivery system compositions containing dyes will be investigated. The results will provide more detailed and precise knowledge regarding structure-activity relationships.