Dr. Grigorjeva et.al. (Organic Synthesis Methodology group) have developed an efficient method for the synthesis of 3-hydroxymethyl isoindolinones via cobalt-catalyzed C(sp2)–H carbonylation of phenylglycinol derivatives using picolinamide as a traceless directing group.
Authors have demonstrated synthetic route that offers a broad substrate scope, excellent regioselectivity, and full preservation of the original stereochemistry providing a pathway for accessing valuable enantiopure 3-substituted isoindolinone derivatives.
This method is published in the high- impact ACS journal – Organic Letters (IF=6.555, 2018):
Lukass Lukasevics, Aleksandrs Cizikovs, Liene Grigorjeva*
Synthesis of 3-Hydroxymethyl Isoindolinones via Cobalt-Catalyzed C(sp2)–H Carbonylation of Phenylglycinol Derivatives. Org. Lett. 2020, DOI: 10.1021/acs.orglett.0c00672
This research was financially supported by ERDF project Nr.188.8.131.52/17/A/004.