Dr. Grigorjeva et.al. (Organic Synthesis Methodology group) have developed a new method for cobalt catalyzed C(sp2)-H functionalization of phenylglycinol derivatives with terminal and internal alkynes directed by picolinamide auxiliary. Elaborated method offers an efficient and highly regioselective route for the synthesis of 1-hydroxymethyltetrahydroisoquinolines.
The Journal of Organic Chemistry (IF=4.745, 2018) accepted this methodology for publication:
Jekaterina Bolsakova, Lukass Lukasevics, Liene Grigorjeva*
Cobalt-catalyzed, directed C-H functionalization/annulation of phenylglycinol derivatives with alkynes. J. Org. Chem. 2020, DOI: 10.1021/acs.joc.0c00207
This research was financially supported by ERDF project Nr.22.214.171.124/17/A/004.