New research identifies novel synthetic multitarget ligands for the free fatty acid receptors

A multi-target approach in drug discovery is a promising approach in drug discovery. It is the opposite of the traditional path and paradigm of ligand-receptor interactions postulated as “one compound—one target”.

Researchers from prof. Gunars Duburs (LIOS) and prof. Janis Kloviņš (Latvian Biomedical Research and Study Centre) groups have identified several groups of compounds possessing multitarget activity towards G-protein-coupled receptors – free fatty acid receptors 2 and 3 (FFA2/GPR43 and FFA3/GPR41) and the hydroxycarboxylic acid receptor 2 (HCA2/GPR109A).

This study also has helped to characterise the similarity in the action of the test compounds on the short-chain fatty acid receptors FFA2/GPR43 and FFA3/GPR41, as well as to compare their activity towards the hydroxycarboxylic acid receptor HCA2/GPR109A and these data will be useful for further development of multitarget ligands.

The research is published in the journal “Pharmaceuticals” (IF = 5.68).

Read the article:

Bisenieks, E; Vigante, B.; Petrovska, R.; Turovska, B.; Muhamadejev, R.; Soloduns, V.; Velena, A.; Pajuste, K.; Saso, L.; Klovins, J.; Duburs, G.*; Mandrika, I.*
The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A
Pharmaceuticals 2021, 14(10), 987. DOI: 10.3390/ph14100987