European Scientists Unite to Investigate an Unexplored Protein

Dr Liga Zvejniece, Lead Researcher at the OSI Laboratory of Pharmaceutical Pharmacology, has been elected Vice-Chair of SIGMA-1 EUROPE (CA23156) COST, an international association of scientists. This association brings together researchers from 24 European countries, each working across various disciplines to investigate the Sigma-1 protein, which remains largely uncharted. Their collective aim is to deepen understanding of the protein’s role in human physiology and pathology, and to explore potential applications of this knowledge in disease treatment. The association will be led by Dr Tangui Maurice, Senior Researcher at INSERM, France.

The Sigma-1 receptor (S1R) is found in various tissues, including cardiac muscle and brain cells, and plays a critical role in cellular processes such as calcium ion transport and neurotransmitter release. S1R has been implicated in the development of diseases such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, stroke, and heart attack. Research suggests that both S1R activators and inhibitors, as well as modulators, may protect cells and improve outcomes in the treatment of these conditions.

SIGMA-1 EUROPE will form transnational teams based on research directions and scientific interests. Over the next four years, these teams will work collaboratively and strategically to elucidate the significance and potential of the S1R receptor, with the ultimate aim of applying this knowledge to enhance human health.

Photo: Liga Zvejniece and Tangui Maurice in the center of the group