Biological properties of self-assembling synthetic lipids have been reported

Multiple biological properties of self-assembling synthetic lipids studied by researchers from the Laboratory of Membrane Active Compounds and β-diketones (LIOS) have been published in the journal “Oxidative Medicine and Cellular Longevity” (IF = 5.076, 2019).

In this paper, the authors demonstrated the biological properties of synthetic lipid self-assembling synthetic lipids – cationic 1,4-dihydropyridines, dihydropyridones and  aminovinylcarbonyl compounds as their open-chain analogues. The obtained results may serve as guidelines for the development of new drug formulations in cancer treatment.

Rucins, M.; Smits, R.; Sipola, A.; Vigante, B.; Domracheva, I.; Turovska, B.; Muhamadejev, R.; Pajuste, K.; Plotniece, M.; Sobolev , A.; Duburs, G.;* Plotniece, A.*
Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds.
Oxid. Med. Cell. Longev. 2020, 8413713. DOI: 10.1155/2020/8413713

This research was supported by the PostDocLatvia Project Nr. “Bifunctional Amphiphilic Lipid-Like Compounds—Self-Assembling Properties and Biological Activities” (to M. Rucins) and EuroNanoMed2 Project INNOCENT “Innovative Nanopharmaceuticals: Targeting Breast Cancer Stem Cells by a Novel Combination of Epigenetic and Anticancer Drugs with Gene Therapy.”