Pharmacomodulators synthesis group

Dr. chem. Pavel Arsenyan
Group leader
Phone: (+371) 29849464

Organic synthesis, chemistry of selenium and tellurium and antitumor activity investigations, development of new methods in heterocyclic chemistry, organometallic chemistry, transition metal and phase transfer catalysis, elaboration of eco-friendly synthetic methods.

Selected publications

  • Ivanova A.; Arsenyan, P. Rise of diselenides: Recent advances in the synthesis of heteroarylselenides. Coord. Chem. Rev., 2018, 370, 55–68.
  • Domracheva I.; Kanepe-Lapsa I.; Jackevica L.; Vasiļjeva J.; Arsenyan P. Selenopheno quinolinones and coumarins promote cancer cell apoptosis by ROS depletion and caspase-7 activation. Life Sci. 2017, 186, 92-101.
  • Paegle E.; Domracheva I.; Turovska B.; Petrova M.; Kanepe-Lapsa I.; Gulbe A.; Liepinsh E.; Arsenyan P. Natural-Antioxidant-Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity. Chem. Asian J. 2016, 11(13), 1929-1938.
  • Arsenyan, P., Vasiljeva, J., Belyakov, S., Liepinsh, E., Petrova, M. Fused Selenazolinium Salt Derivatives with a Se-N+ Bond: Preparation and Properties. Eur. J. Org. Chem., 2015 (26), 5842-5855.
  • Arsenyan, P., Paegle, E., Domracheva, I., Gulbe, A., Kanepe-Lapsa, I., Shestakova, I.Selenium analogues of raloxifene as promising antiproliferative agents in treatment of breast cancer. Eur. J. Med. Chem., 2014, 87, 471-483.