Laboratory of Carbofunctional Compounds

Dr. chem. Olga Bobiļeva
Head of Laboratory


The Laboratory of Carbofunctional Compounds researchers have extensive expertise in small-molecule medicinal chemistry – anti-cancer drug discovery, G-protein coupled receptors ligands research, development of new antibiotics and antivirals. The laboratory team is engaged in publicly funded projects as well as in custom synthesis.

Selected publications

  • Bobiļeva, O., Bobrovs, R., Kaņepe, I., Patetko, L., Kalniņš, G., Šišovs, M., Bula, A.L., Grīnberga, S.,Borodušķis, M.,Ramata-Stunda, A., Rostoks, N., Jirgensons, A., Tārs, K., Jaudzems, K. Potent SARS-CoV‑2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate. ACS Medicinal Chemistry Letters, 2021, 12 (7), pp 1102-1107.
  • Liao, C., Zhang, Y., Fan, C., Herring, L.E., Liu, J., Locasale, J.W., Takada, M., Zhou, J., Zurlo, G., Hu, L., Simon, J.M., Ptacek, T.S., Andrianov, V.G., Loza, E., Peng, Y., Yang, H., Perou, C.M., Zhang, Q. Identification of bbox1 as a therapeutic target in triple-negative breast cancer. Cancer Discovery, 2020, 10 (11), pp. 1707-1721.
  • Loza, E., Sarciaux, M., Ikaunieks, M., Katkevics, M., Kukosha, T., Trufilkina, N., Ryabova, V., Shubin, K., Pantel, L., Serri, M., Huseby, D.L., Cao, S., Yadav, K., Hjort, K., Hughes, D., Gualtieri, M., Suna, E., Racine, E. Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues. Bioorganic and Medicinal Chemistry, 2020, 28 (11), art. no. 115469.
  • Charlton, M.H., Aleksis, R., Saint-Leger, A., Gupta, A., Loza, E., Ribas De Pouplana, L., Kaula, I., Gustina, D., Madre, M., Lola, D., Jaudzems, K., Edmund, G., Randall, C.P., Kime, L., O’Neill, A.J., Goessens, W., Jirgensons, A., Finn, P.W. N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors. ACS Medicinal Chemistry Letters, 2018, 9 (2), pp. 84-88.
  • Bobileva, O., Ikaunieks, M., Duburs, G., Mandrika, I., Petrovska, R., Klovins, J., Loza, E. Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists. Bioorganic and Medicinal Chemistry, 2017, 25 (16), pp. 4314-4329.