A method for quantitative NMR based on residual CDCl3 signal has been reported

A researcher group from LIOS has proposed a very simple method for a fast determination of NMR yield in the organic synthesis lab by determining residual solvent concentration in each CDCl3 batch and using the residual solvent signal as an internal standard. This approach has a huge potential in reaction optimization and fast purity assessment of the reaction intermediates and common lab chemicals without the necessity to add any foreign materials to the sample. The research has been published in the Journal of Organic Chemistry (IF 2019: 4.335).

Muhamadejev,R.; Melngaile, R.; Paegle, P.; Zibarte, I.; Petrova, M., Jaudzems, K.; Veliks, J.*
Residual Solvent Signal of CDCl3 as a qNMR Internal Standard for Application in Organic Chemistry Laboratory.  J. Org. Chem. 2021. DOI:10.1021/acs.joc.0c02744