Research on New Calcium Ion Transport Modulators

Dr. Domracheva have published studies about novel 4-pyridinio-1,4-dihydropyridine (1,4-DHP) derivatives possessing calcium channel modulating activity.  The antagonist, agonist, and dual-action effect of the 1,4-DHP were evaluated.  The research is published in the journal “Oxidative Medicine and Cellular Longevity” (IF=4.868, 2018).

Ilona Domracheva*, Iveta Kanepe-Lapsa, Reinis Vilskersts, Imanta Bruvere, Egils Bisenieks, Astrida Velena*, Baiba Turovska, Gunars Duburs.
4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action.
Oxid. Med. Cell. Longev. 2020, 2075815, DOI 10.1155/2020/2075815

This research was financially supported by Latvian Council of Science, National Research Programme PUBLIC HEALTH/Biomedicine of the Republic of Latvia, as well as projects NFI/R/2014/051 and INNOVABALT (REGPOT-CT-2013-316149).

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