Lietderīgās ķīmijas grupa

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Dr. chem. Raivis Žalubovskis
Grupas vadītājs
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Telefons: +371 67014826

Publikācijas

  1. Grandane, A.; Tanc, M.; Di Cesare Mannelli, L.; Carta, L.; Ghelardini, C.; Žalubovskis, R.; Supuran, C.T. 6‑Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells. J.  Med. Chem. 2015, 58, 3975-3983.
  2. Ivanova, J.; Leitans, J.; Tanc, M.; Kazaks, A.; Zalubovskis, R.; Supuran, C.T.; Tars, K. X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors. Chem. Commun. 2015, 51, 7108-7111.
  3. Alterio, V.; Tanc, M.; Ivanova, J.; Zalubovskis, R.; Vozny, I.; Monti, S. M.; Di Fiore, A.; De Simone, G.; Supuran, C. T. X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor. Org. Biomol. Chem. 2015, 13, 4064-4069.
  4. Grandane, A.; Tanc, M.; Žalubovskis, R.; Supuran, C.T. Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action. J. Med. Chem. 2015, 23, 1430-1436.
  5. De Simone, G.; Pizika, G.; Monti, S.M.; Di Fiore, A.; Ivanova, J.; Vozny, I.; Trapencieris, P.; Zalubovskis,; Supuran, C.T.; Alterio, V. Hydrophobic substituents of the phenyl-methyl-sulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors. BioMed Research International vol. 2014, Article ID 523210, 11 pages, 2014. doi:10.1155/2014/523210.

Patenti

  1. Žalubovskis R.; Pelšs J.; Voznijs I.; Borovika D.; Kalviņš I. 8-Quinolin- and 8-pyridin-2,6-diaza-bicyclo[2.2.2]octane-3,5-diones as potential anti-cancer and anti-inflammatory agents. LV pat. Appl. P-12-22, 2012.
  2. Urtti A.; Hyvonen Z.; Plotniece A.; Makarova N.; Reine I.; Tirzitis G.; Vigante B.; Cekavicus B.; Shmidlers A.; Krauze A.; Zhalubovskis R.; Duburs G.; Turunen M.; Yla-Herttuala S.; Jaaskelainen I.; Toppinen M.-R. Cationic amphiphilic 1,4-dihydropyridine derivatives useful for delivery of nucleotide containing compounds. US 2003/0064954 A1, 3.4, 2003.
  3. Urtti A.; Hyvonen Z.; Plotniece A.; Makarova N.; Reine I.; Tirzitis G.; Vigante B.; Cekavicus B.; Shmidlers A.; Krauze A.; Zhalubovskis R.; Duburs G.; Turunen M.; Yla-Herttuala S.; Jaaskelainen I.; Toppinen M.-R. Cationic amphiphilic 1,4-dihydropyridine derivatives useful for delivery of nucleotide containing compounds. AU 3931301 (A), 3.9, 2001.
  4. Plotniece A.; Turunen M.; Tirzitis G.; Reine I.; Makarova N.; Hyvonen Z.; Urtti A.; Duburs G.; Shmidlers A.; Yla-Herttuala S.; Zhalubovskis R.; Cekavicus B.; Krauze A.; Vigante B.; Toppinen M.-R.; Jaaskelainen I. Cationic amphiphilic 1,4-dihydropyridine derivatives useful for delivery of nucleotide containing compounds. Derives cationiques amphiphiles de 1,4-dihydropyridine utiles pour l,administration de composants renfermant des nucleotides. CA 2 397 669 A1, 30.8, 2001.
  5. Urtti A.; Hyvonen Z.; Plotniece A.; Makarova N.; Zhalubovskis R.; Duburs G.; Turunen M.; Yla-Herttuala S.; Jaaskelainen I.; Toppinen M.-R.; Reine I.; Tirzitis G.; Vigante B.; Cekavicus B.; Shmidlers A.; Krauze A. Cationic amphiphilic 1,4-dihydropyridine derivatives useful for delivery of nucleotide containing compounds . PCT/FI01/00185, 22.02.2001. WO 01/62946 A1, 30.8, 2001.