Heterociklisko savienojumu sintēzes grupa

Maksims_Vorona-3

 

Dr. chem. Maksims Vorona
Grupas vadītājs
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Heterociklisko savienojumu sintēzes grupa nodarbojas ar bioloģiski aktīvu pirolidonu un pirolinonu atvasinājumu sintētisko metožu izstrādi.

Izvēlētas publikācijas:

  1. Veinberg, E. Vavers, N. Orlova, J. Kuznecovs, I. Domracheva, M. Vorona, L. Zvejniece, M. Dambrova. Stereochemistry of phenylpiracetam and its methyl derivative: improvement of pharmacological profile. Chem. Heterocycl. Comp, 2015, 51(7), 601-606.
  2. Veinberg, I. Potorocina, M. Vorona, Recent Trends in the Design, Synthesis and Biological Exploration of b-Lactams, Curr Med Chem. 2014, 21 (4), 393-416.
  3. Zvejniece, E. Vavers, B. Svalbe, R. Vilskersts, M. Vorona, G. Veinberg, I. Misane, I. Stonans, I. Kalvinsh and M. Dambrova, The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors. British Journal of Pharmacology, 2014, 171, 761-771.
  4. Veinberg G.*, Vorona, Zvejniece L., Vilskersts R., Vavers E., Liepinsh E., Kazoka H., Belyakov S., Mishnev A., Kuznecovs J., Vikainis S., Orlova N., Lebedev A., Ponomaryov Y., Dambrova M. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg. Med. Chem., 2013, 21 (10), 2764-2771.
  5. Vorona, N. Orlova, J. Kuznecovs, S. Vikainis, E. Liepinsh, S. Belyakov, A. Mishmev, G. Veinberg*, Method for the preparation of 4-aryl-3-pyrrolin-2-ones and their 5-bromo derivatives, Heterocycl. Comp, 2013, 8,1118-1127.