Studies on carbonic anhydrases inhibitors

Continuing studies in the field of carbonic anhydrases (CA) inhibitors, professors R. Žalubovskis’ (LIOS) and Claudiu T. Supuran’s groups published an article in the Journal of Enzyme Inhibition and Medicinal Chemistry (IF=4.027, 2018).  Authors described the synthesis of a new series of homosulfocoumarins and investigated for the inhibition of four physiologically relevant CA isoforms –  the human (h) hCA I, II, IX and XII.

Pustenko, A., Nocentini, A., Balašova, A., Alafeefy, A., Krasavin, M., Žalubovskis, R., Supuran, C.T.
Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors
J. Enzyme Inhib. Med. Chem. 2020, 35, p. 245-254, https://doi.org/10.1080/14756366.2019.1695795

The research was supported by ERA.Net RUS plus joint programme project THIOREDIN (State Education Development Agency of Republic of Latvia) [grant number RUS_ST2017-309] and the Russian Foundation for Basic Research [grant number 18–515-76001].