Studies of enzyme Sortase A inhibitors by prof. Jaudzems group (Laboratory of Physical Organic Chemistry) and scientists from Latvian Biomedical Research and Study Centre has been published in the ACS Infectious Diseases (IF 4.911, 2018):
Kristaps Jaudzems, Viktorija Kurbatska, Atis Jēkabsons, Raitis Bobrovs, Zhanna Rudevica, Ainars Leonchiks.
Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization
ACS Infect. Dis. 2019, DOI: 10.1021/acsinfecdis.9b00265
Enzyme sortase A has become an attractive target for the development of new antivirulence drugs against Gram-positive infections. 27 compounds as covalent inhibitors of Sortase A has been identified. These compounds have a potential to be developed into broad spectrum antivirulence agents.