Novel method for cobalt catalyzed C(sp2)-H functionalization of phenylglycinol derivatives

Dr. Grigorjeva et.al. (Organic Synthesis Methodology group) have developed a new method for cobalt catalyzed C(sp2)-H functionalization of phenylglycinol derivatives with terminal and internal alkynes directed by picolinamide auxiliary. Elaborated method offers an efficient and highly regioselective route for the synthesis of 1-hydroxymethyltetrahydroisoquinolines.

The Journal of Organic Chemistry (IF=4.745, 2018) accepted this methodology for publication:

Jekaterina Bolsakova, Lukass Lukasevics, Liene Grigorjeva*
Cobalt-catalyzed, directed C-H functionalization/annulation of phenylglycinol derivatives with alkynes. J. Org. Chem. 2020, DOI: 10.1021/acs.joc.0c00207

jo0c00207_0010-2

This research was financially supported by ERDF project Nr.1.1.1.5/17/A/004.