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Conferences
Rucins M.; Kl. Pajuste; Vezane A.; Dimitrijevs P.; Timofejeva A.; Vigante B.; Gosteva M.; Plotniece M.; Sobolev A.; K. Pajuste; Kozlovska T.; Plotniece A. Gene delivery systems based on synthetic lipid-like 1,4-dihydropyridine core – relationships of self-assembling and physicochemical properties.. 1st CA 17140 COST Conference “Cancer Nanomedicine – from the Bench to the Bedside”; Riga, Latvia, October 15-17, 2019; 68.      

Петухов В.И.; Дмитриев Д.В.; Баумане Л.Х.; Скальный A.B. CИНХРОННОСТЬ РАБОТЫ МЕМБРАННЫХ ПОМП В ЭПИДЕРМИСЕ: ВОЗМОЖНОСТЬ КОЛИЧЕСТВЕННОЙ ОЦЕНКИ УРОВНЯ СИНХРОНИЗАЦИИ. Mатериалы Международной конференции NT + M&Ec`2019, ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ, БИОЛОГИИ, ФАРМАКОЛОГИИ И ЭКОЛОГИИ; Гурзуф, 01-11 июня, 2019; 248.      

Upmanis T.; Kazoka H.; Arsenyan P. Chiral resolution of Tyr-Arg-Phe-Lys-NH2 tetrapeptide stereoisomers on crown ether based chiral stationary phases. 12th Balaton Symposium on High-Performance Separation Methods; Siofok, Hungary, September 11-13, 2019.      

Rucins M.; Dimitrijevs P.; Smits K.; K. Pajuste; Sobolev A.; Domracheva I.; Plotniece A. 4-(N-Alkylpyridinium)-1,4-Dihydropyridines as Bifunctional Lipid-Like Compounds for Self-Assembling and Biological Studies. 1st Romanian International Conference on Chemistry and Chemical Engineering; Constanta, Romania, September 4-7, 2019.      

Ruciņš M.; Plotniece M.; Dimitrijevs P.; Domracheva I.; Smits K.; Tirzite D.; K. Pajuste; Sobolev A.; Plotniece A. Lipid-like 4-(N-alkylpyridinium)-1,4-dihydropyridines – contribution of molecular structure to self-assembling and biological properties. 33rd Conference of The European Colloid and Interface Society; Leuven, Belgium, September 8-13, 2019.      

Dimitrijevs P.; K. Pajuste; Korotkaja K.; Rucins M.; Plotniece M.; Kl. Pajuste; Bandere D.; Sobolev A.; Zajakina A.; Plotniece A. Interaction of liposomes formed by synthetic and natural lipids with phospholipid model membrane in Langmuir monolayer. 33rd Conference of The European Colloid and Interface Society; Leuven, Belgium, September 8-13, 2019.      

Mišņevs A. ON PHASING OF OVERSAMPLED DIFFRACTION DATA. European Crystallographic Meeting; Vienna, Austria, August 18-23, 2019.      

Krukle-Berzina K.; Mišņevs A. ; Belakovs S.; Shubin Kirill STABILITY OF NON‐TOXIC GAMMA‐CYCLODEXTRIN‐BASED METAL-ORGANIC FRAMEWORK IN VARIOUS SOLVENTS. European Crystallographic Meeting (ECM32); Vienna, Austria, August 18-23, 2019.      

Upmanis T.; Kažoka H.; Orlova N.; Vorona M. Enantioseparation of 4C substituted pyrrolidin-2-one derivatives on polysaccharide-based coated chiral stationary phases. 48th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (HPLC2019); Milan, Italy, June 16-20, 2019.      

Theses
*Leonova E. DNA-binding and DNA-protection properties of novel 1,4- dihydropyridine derivatives. Dr. biol., Latvijas Universitāte, Rīga, 2019.      

Voļska K. Metil-gbb aizsargājošo efektu un darbības mehānismu izpēte diabēta un tā komplikāciju eksperimentālajos modeļos. Promocijas darbs farmācijas doktora zinātniskā grāda iegūšanai (Dr. pharm.), Rīgas Stradiņa universitāte, Rīga, 2019.      

Kinens A. Lewis Base Catalysts by Chiral DMAP species. Promocijas darbs ķīmijas doktora zinātniskā grāda organiskajā ķīmijā iegūšanai (Dr.chem.), Latvijas Universitāte, Rīga, 2019.      

Nikitjuka A. Metaloproteināžu HDAC un ADAM potenciālo inhibitoru iegūšana un ar to saistīta sintēzes metožu izveide. Promocijas darbs ķīmijas doktora zinātniskā grāda organiskajā ķīmijā iegūšanai (Dr.chem.), Latvijas Universitāte, Rīga, 2019.      

Leitis Z. Jaunas metodes hirālu 4-aril-3,4-dihidrokumarīnu sintēzē. Promocijas darbs ķīmijas zinātņu doktora grāda iegūšanai (Dr.chem.), RTU, Rīga, 2019.      

Bobileva O. Hidroksikarbonskābju sintētisko ligandu pētījumi. Promocijas darbs ķīmijas zinātņu doktora grāda iegūšanai (Dr.chem.), RTU, Rīga, 2019.      

Publications indexed in Scopus database
Colella M.; Musci P.; Luisi R.; *Degennaro L. Synthesis and use of halodifluoromethyl heterocycles. Targets Heterocycl. Syst. 2019, 23, 384-398.      

Filimonov V.O.; Dianova L.N.; Beryozkina T.V.; Mazur D.; Beliaev N.A.; Volkova N.N.; Ilkin V.G.; Dehaen W.; Lebedev A.T.; *Bakulev V.A. Water/Alkali-Catalyzed Reactions of Azides with 2-Cyanothioacetamides. Eco-Friendly Synthesis of Monocyclic and Bicyclic 1,2,3-Thiadiazole-4-carbimidamides and 5-Amino-1,2,3-triazole-4-carbothioamides. J. Org. Chem. 2019, 84(21), 13430-13446.      

Beliaev N.A.; Beryozkina T.V.; Lubec G.; *Bakulev V.A. A catalyst-free one-step synthesis of N-pyrimidinyl amidines from endocyclic enamines and 4-azidopyrimidines. Mendeleev Commun. 2019, 29(1), 50-52.      

Lauder K.; Masci D.; Toscani A.; Al Mekdad A.; Black G.W.; Brown N.L.; Turner N.J.; Luisi R.; *Castagnolo D. A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution. Org. Biomol. Chem. 2019, 17(40), 8982-8986.      

Colella M.; Tota A.; Grossjohann A.; Carlucci C.; Aramini A.; *Sheikh N.S.; Degennaro L.; Luisi R. Straightforward chemo- and stereoselective fluorocyclopropanation of allylic alcohols: Exploiting the electrophilic nature of the not so elusive fluoroiodomethyllithium. Chem. Commun. 2019, 55(58), 8430-8433.      

Musci P.; Colella M.; Fanelli F.; Altomare A.; Pisano L.; Carlucci C.; *Luisi R.; Degennaro L. Stereo-and enantioselective addition of organolithiums to 2-oxazolinylazetidines as a synthetic route to 2-acylazetidines. Front. Chem. 2019, 7.      

*Carlucci C.; Degennaro L.; Luisi R. Titanium dioxide as a catalyst in biodiesel production. Catalysts 2019, 9(1).      

Kaldmae M.; Leppert A.; Chen G.; Sarr M.; Sahin C.; Nordling K.; Kronqvist N.; Gonzalvo-Ulla M.; Fritz N.; Abelein A.; Laiotan S.; Biverstal H.; Jornvall H.; Lane D.P.; *Rising A.; Johansson J.; Landreh M. High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry. FEBS J. 2019.      

Sjakste T.; Leonova E.; Petrovs R.; Roder M.; *Sjakste N. S-6. Guanine-quadruplexenriched sequences in the tight DNA-protein complexes of barley seedlings. Bioplym. Cell 2019, 35(3), 234.      

*Jaudzems K.; Kurbatska V.; Jekabsons A.; Bobrovs R.; Rudevica Z.; Leonchiks A. Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization. ACS Infect. Dis. 2019.      

Leduskrasts K.; Kinēns A.; *Suna E. Cation-π interactions secure aggregation induced emission of planar organic luminophores. Chem. Commun. 2019, 55(84), 12663-12666.      

Kumpiņa I.; Brodyagin N.; MacKay J.A.; Kennedy S.D.; Katkevics M.; *Rozners E. Synthesis and RNA-Binding Properties of Extended Nucleobases for Triplex-Forming Peptide Nucleic Acids. J. Org. Chem. 2019, 84(21), 13276-13298.      

*Olek R.A.; Samulak J.J.; Sawicka A.K.; Hartmane D.; Grinberga S.; Pugovičs O.; Lysiak-Szydlowska W. Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women. Oxidative Med. Cell. Longevity 2019, 2019.      

Kauss V.; Dambrova M.; *Medina D.L. Pharmacological approaches to tackle NCLs. Biochim. Biophys. Acta Mol. Basis Dis. 2019.      

Rodrigo E.; Baunis H.; Suna E.; *Waldvogel S.R. Simple and scalable electrochemical synthesis of 2,1-benzisoxazoles and quinoline: N -oxides. Chem. Commun. 2019, 55(81), 12255-12258.      

*Leitis Z. Synthesis of phenyl ring substituted 4-aryl-3,4-dihydrocoumarines. Key Eng Mat 2019, 800 KEM, 3-8.      

Richichi B.; Spyroulias G.A.; Winum J.-Y.; Žalubovskis R. Metalloenzymes as therapeutic targets. Curr. Med. Chem. 2019, 26(15), 2556-2557.      

*Žalubovskis R.; Winum J.-Y. Inhibitors of selected bacterial metalloenzymes. Curr. Med. Chem. 2019, 26(15), 2690-2714.      

*Ciubotaru M.; Musat M.G.; Surleac M.; Ionita E.; Petrescu A.J.; Ābele E.; Abele R. The design of new HIV-IN tethered bifunctional inhibitors using multiple microdomain targeted docking. Curr. Med. Chem. 2019, 26(15), 2574-2600.      

*Arsenyan P.; Lapcinska S.; Ivanova A.; Vasiļjeva J. Peptide Functionalization Through the Generation of Selenocysteine Electrophile. Eur. J. Org. Chem. 2019, 2019(30), 4951-4961.      

*Romanchikova N.; Trapencieris P. Wedelolactone targets EZH2-mediated histone H3K27 methylation in mantle cell Lymphoma. Anticancer Res. 2019, 39(8), 4179-4184.      

*Arsenyan P.; Vasiļjeva J.; Domracheva I.; Kanepe-Lapsa I.; Gulbe A. Selenopheno[2,3-: F] coumarins: Novel scaffolds with antimetastatic activity against melanoma and breast cancer. New J. Chem. 2019, 43(30), 11851-11864.      

Zvejniece L.; Dambrova M.; *Šmits G. Total synthesis and in vivo evaluation of 8-deoxypumiliotoxin 193H. Nat. Prod. Res. 2019.      

*Pikun N.V.; Kolesnyk N.P.; Rusanov E.B.; Plotniece A.; Sobolev A.; Domracheva I.; Shermolovich Y.G. Contrasting reactivity of fluorinated 2,6-heptanediones towards amines and ammonia, leading to cyclohexanediones or 2-oxa-6-azabicyclo[2.2.2]octanes and evaluation of their cytotoxicity. New J. Chem. 2019, 43(26), 10537-10544.      

*Vāvers E.; Zvejniece L.; Maurice T.; Dambrova M. Allosteric modulators of sigma-1 receptor: A review. Front. Pharmacol. 2019, 10(MAR).      

Dar'in D.; Kantin G.; Bakulina O.; Žalubovskis R.; *Krasavin M. Flexible Entry into 3-Arylpent-2-enedioic Acids via Heck-Matsuda Arylation of Dimethyl Glutaconate with Arenediazonium Tosylates. Synthesis 2019, 51(10), 2230-2236.      

*Tsai W.-B.; Ng S.C.; Bernotiene E.; Sobolev A. Proteoglycan/gelatin hydrogel via enzymatic gelation for tissue engineering applications. Trans. Annu. Meet. Soc. Biomater. Annu. Int. Biomater. Symp. 2019, 40, 945.      

Konrāde I.; Zavorikina J.; Fridvalde A.; Rots D.; Kalere I.; Strumfa I.; Dambrova M.; *Gailite L. Novel variant of the androgen receptor gene in a patient with complete androgen insensitivity syndrome and polyorchidism. Front. Endocrinol. 2019, 10(JAN).      

Tumosiene I.; *Kantminiene K.; Jonuskiene I.; Peleckis A.; Belyakov S.; Mickevicius V. Synthesis of 1-(5-Chloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives and Their Antioxidant Activity. Molecules 2019, 24(5).      

*Arsenyan P.; Vasiļjeva J.; Ivanova A.; Belyakov S. Unusual N,Se-heterocycles with cyclic Se–N + bond of isoselenazolopurinium type. Mendeleev Commun. 2019, 29(1), 96-98.      

Bakulina O.; Bannykh A.; Jovanovic M.; Domračeva I.; Podolski-Renič A.; Žalubovskis R.; Pesic M.; Dar'in D.; *Krasavin M. Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols. J. Enzyme Inhib. Med. Chem. 2019, 34(1), 665-671.      

Dumont E.; Vergalli J.; Pajovic J.; Bhamidimarri S.P.; Morante K.; Wang J.; Lubriks D.; Suna E.; Stavenger R.A.; Winterhalter M.; Refregiers M.; *Pages J.-M. Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm. Life Sci. Alliance 2019, 2(1).      

Leduskrasts K.; *Suna E. Aggregation induced emission by pyridinium-pyridinium interactions. RSC Adv. 2019, 9(1), 460-465.      

*Heuser J.M.; Zarins A.; Baumane L.; Kizane G.; Knitter R. Radiation stability of long-term annealed bi-phasic advanced ceramic breeder pebbles. Fusion Eng Des 2019, 138, 395-399.      

*Luginina J.; Vasiljevs D.; Ivanovs I.; Mishnev A.; Turks M. Diastereoselective aza-Michael addition for synthesis of carbohydrate-derived spiropiperazinones. Monatsh. Chem. 2019, 150(1), 21-28.      

*Mierina I.; Stikute A.; Mishnev A.; Jure M. An alternative way to analogues of avenanthramides and their antiradical activity. Monatsh. Chem. 2019, 150(1), 85-101.      

Magalhaes J.; Franko N.; Annunziato G.; Pieroni M.; Benoni R.; Nikitjuka A.; Mozzarelli A.; Bettati S.; Karawajczyk A.; Jirgensons A.; Campanini B.; *Costantino G. Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms. J. Enzyme Inhib. Med. Chem. 2019, 34(1), 31-43.      

Hyde S.; Veliks J.; Ascough D.M.H.; Szpera R.; Paton R.S.; *Gouverneur V. Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides. Tetrahedron 2019, 75(1), 17-25.      

*Joy M.N.; Bakulev V.A. Is nonaflate a better leaving group than corresponding triflate? A case study in the palladium catalyzed cross-coupling reaction of 7-substituted coumarins. AIP Conf. Proc. 2019, 2063.      

*Kviesis J.; Klimenkovs I.; Arbidans L.; Podjava A.; Klavins M.; Liepiņš E. Evaluation of furanocoumarins from seeds of the wild parsnip (Pastinaca sativa L. s.l.). J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2019, 1105, 54-66.      

Monticelli S.; Colella M.; Pillari V.; Tota A.; Langer T.; Holzer W.; Degennaro L.; *Luisi R.; Pace V. Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and Aziridines via the Addition of Fluoroiodomethyllithium to Carbonyl-Like Compounds. Org. Lett. 2019, 21(2), 584-588.      

Karpov Y.; Kiriy N.; Formanek P.; Zessin J.; Hambsch M.; Mannsfeld S.C.B.; Lissel F.; Beryozkina T.; Bakulev V.; Voit B.; *Kiriy A. Layer-by-Layer Assembly Enabled by the Anionic p-Dopant CN6-CP•-K+: A Route to Achieve Interfacial Doping of Organic Semiconductors. ACS Appl. Mater. Interfaces 2019, 11(4), 4159-4168.      

Grandāne A.; Longwitz L.; Roolf C.; Spannenberg A.; Escobar H.M.; Junghanss C.; Suna E.; *Werner T. Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones. J. Org. Chem. 2019, 84(3), 1320-1329.      

Zogota R.; Kinēna L.; Withers-Martinez C.; Blackman M.J.; Bobrovs R.; Pantelejevs T.; Kanepe-Lapsa I.; Ozola V.; Jaudzems K.; Suna E.; *Jirgensons A. Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D. Eur. J. Med. Chem. 2019, 163, 344-352.      

Samulak J.J.; Sawicka A.K.; Hartmane D.; Grinberga S.; Pugovičs O.; Lysiak-Szydlowska W.; Olek R.A. L-Carnitine supplementation increases trimethylamine-N-oxide but not markers of atherosclerosis in healthy aged women. Ann. Nutr. Metab. 2019, 74(1), 11-17.      

Otikovs M.; Olsen G.L.; Kupče Ē.; *Frydman L. Natural Abundance, Single-Scan 13C-13C-Based Structural Elucidations by Dissolution DNP NMR. J. Am. Chem. Soc. 2019, 141(5), 1857-1861.      

*Bakulev V.; Shafran Y.; Dehaen W. Progress in intermolecular and intramolecular reactions of thioamides with diazo compounds and azides. Tetrahedron Lett. 2019, 60(7), 513-523.      

Sisulins A.; Bucevicius J.; Tseng Y.-T.; Novosjolova I.; Traskovskis K.; Bizdēna Ē.; Chang H.-T.; *Tumkevicius S.; Turks M. Synthesis and fluorescent properties of N(9)-alkylated 2-amino-6-triazolylpurines and 7-deazapurines. Beilstein J. Org. Chem. 2019, 15, 474-489.      

Tambaro S.; Galan-Acosta L.; Leppert A.; Chen G.; Biverstal H.; Presto J.; Nilsson P.; *Johansson J. Blood– brain and blood– cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice. J. Biol. Chem. 2019, 294(8), 2606-2615.      

Ruciņš M.; Dimitrijevs P.; Pajuste K.; Petrichenko O.; Jackevica L.; Gulbe A.; Kibilda S.; Smits K.; Plotniece M.; Tirzīte D.; Pajuste K.; Sobolev A.; Liepins J.; Domracheva I.; *Plotniece A. Contribution of molecular structure to self-assembling and biological properties of bifunctional lipid-like 4-(N-alkylpyridinium)-1,4-Dihydropyridines. Pharmaceutics 2019, 11(3).      

De Bruyne T.; Steenput B.; Roth L.; De Meyer G.R.Y.; Dos Santos C.N.; Valentova K.; Dambrova M.; *Hermans N. Dietary polyphenols targeting arterial stiffness: Interplay of contributing mechanisms and gut microbiome-related Metabolism. Nutrients 2019, 11(3).      

Vigante B.; Leitonas K.; Volyniuk D.; Andruleviciene V.; Simokaitiene J.; Ivanova A.; Bucinskas A.; *Grazulevicius J.V.; Arsenyan P. Synthesis of Linear and V-Shaped Carbazolyl-Substituted Pyridine-3,5-dicarbonitriles Exhibiting Efficient Bipolar Charge Transport and E-Type Fluorescence. Chem. Eur. J. 2019, 25(13), 3325-3336.      

Brennecke P.; Rasiņa D.; Aubi O.; Herzog K.; Landskron J.; Cautain B.; Vicente F.; Quintana J.; Mestres J.; Stechmann B.; Ellinger B.; Brea J.; Kolanowski J.L.; Pilarski R.; Orzaez M.; Pineda-Lucena A.; Laraia L.; Nami F.; Zielenkiewicz P.; Paruch K.; Hansen E.; von Kries J.P.; Neuenschwander M.; Specker E.; Bartunek P.; Simova S.; Lesnikowski Z.; Krauss S.; Lehtio L.; Bilitewski U.; Bronstrup M.; Tasken K.; Jirgensons A.; Lickert H.; Clausen M.H.; Andersen J.H.; Vicent M.J.; Genilloud O.; Martinez A.; Nazare M.; *Fecke W.; Gribbon P. EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discov. 2019, 24(3), 398-413.      

*Laipniece L.; Kampars V.; Belyakov S.; Tokmakovs A.; Nitiss E.; Rutkis M. Dendronized azochromophores with aromatic and perfluoroaromatic fragments: Synthesis and properties demonstrating Ar–ArF interactions. Dyes Pigm. 2019, 162, 394-404.      

*Veliks J.; Kazia A. Fluoromethylene Transfer from Diarylfluoromethylsulfonium Salts: Synthesis of Fluorinated Epoxides. Chem. Eur. J. 2019, 25(15), 3786-3789.      

Purins M.; Mishnev A.; *Turks M. Brønsted Acid Catalyzed 1,2-Silyl Shift in Propargyl Silanes: Synthesis of Silyl Dienes and Silyl Indenes. J. Org. Chem. 2019, 84(6), 3595-3611.      

*Honcharenko D.; Juneja A.; Roshan F.; Maity J.; Galan-Acosta L.; Biverstal H.; Hjorth E.; Johansson J.; Fisahn A.; Nilsson L.; Stromberg R. Amyloid-β Peptide Targeting Peptidomimetics for Prevention of Neurotoxicity. ACS Chem. Neurosci. 2019, 10(3), 1462-1477.      

Ivanova J.; Štrumfs B.; *Žalubovskis R. Access to NH-aziridine-2-carboxamides through Davidsen acylimidodicarbonate activation. C. R. Chim. 2019, 22(4), 283-293.      

*Traskovskis K.; Kokars V.; Belyakov S.; Lesina N.; Mihailovs I.; Vembris A. Emission Enhancement by Intramolecular Stacking between Heteroleptic Iridium(III) Complex and Flexibly Bridged Aromatic Pendant Group. Inorg. Chem. 2019, 58(7), 4214-4222.      

Jaudzems K.; Polenova T.; Pintacuda G.; Oschkinat H.; *Lesage A. DNP NMR of biomolecular assemblies. J. Struct. Biol. 2019, 206(1), 90-98.      

Skvorcova M.; Lukasevics L.T.; *Jirgensons A. Amination of Carbenium Ions Generated by Directed Protonolysis of Cyclopropane. J. Org. Chem. 2019, 84(7), 3780-3792.      

Cipa J.; *Zarins A.; Supe A.; Kizane G.; Zolotarjovs A.; Baumane L.; Trinkler L.; Leys O.; Knitter R. X-ray induced defects in advanced lithium orthosilicate pebbles with additions of lithium metatitanate. Fusion Eng Des 2019, 143, 10-15.      

*Pilipenko V.; Narbute K.; Amara I.; Trovato A.; Scuto M.; Pupure J.; Jansone B.; Poikans J.; Bisenieks E.; Kluša V.; Calabrese V. GABA-containing compound gammapyrone protects against brain impairments in Alzheimer’s disease model male rats and prevents mitochondrial dysfunction in cell culture. J. Neurosci. Res. 2019, 97(6), 708-726.      

Beryozkina T.V.; Filimonov V.O.; Dianova L.N.; Slepukhin P.А.; Mazur D.M.; Pospelova T.А.; *Bakulev V.А. Reactions of N-sulfonyl-1,2,3-thiadiazole-4-carbimidamides with sulfonyl chlorides: regiospecific synthesis and structure of 2-sulfonyl-1,2,3-triazoles. Chem. Heterocycl. Compd. 2019, 55(6), 547-553.      

Gupta R.; Zhang H.; Lu M.; Hou G.; Caporini M.; Rosay M.; Maas W.; Struppe J.; Ahn J.; Byeon I.-J.L.; Oschkinat H.; Jaudzems K.; Barbet-Massin E.; Emsley L.; *Pintacuda G.; Lesage A.; Gronenborn A.M.; Polenova T. Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies. J Phys Chem B 2019, 123(24), 5048-5058.      

Reed J.H.; Donets P.A.; Miaskiewicz S.; *Cramer N. A 1,3,2-Diazaphospholene-Catalyzed Reductive Claisen Rearrangement. Angew. Chem. Int. Ed. 2019, 58(26), 8893-8897.      

Lopatina T.V.; Medvedeva N.I.; Baikova I.P.; Iskhakov A.S.; *Kazakova O.B. Synthesis and Cytotoxicity of О- and N-Acyl Derivatives of Azepanobetulin. Russ. J. Bioorg. Chem. 2019, 45(4), 292-301.      

*Borisovs V.; Leonova E.; Baumane L.; Kalnina J.; Mjagkova N.; Sjakste N. Blood levels of nitric oxide and DNA breaks assayed in whole blood and isolated peripheral blood mononucleated cells in patients with multiple sclerosis. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2019, 843, 90-94.      

Shafran Y.M.; Beryozkina T.V.; Efimov I.V.; *Bakulev V.A. Synthesis of β-azolyl- and β-azolylcarbonylenamines and their reactions with aromatic azides. Chem. Heterocycl. Compd. 2019, 55(8), 704-715.      

*Len C.; Luisi R. Catalytic methods in flow chemistry. Catalysts 2019, 9(8).      

*Arsenyan P.; Petrenko A.; Leitonas K.; Volyniuk D.; Simokaitiene J.; Klinavicius T.; Skuodis E.; Lee J.-H.; Grazulevicius J.V. Synthesis and Performance in OLEDs of Selenium-Containing Phosphorescent Emitters with Red Emission Color Deeper Than the Corresponding NTSC Standard. Inorg. Chem. 2019, 58(15), 10174-10183.      

*Kons A.; Be Rzins A.; Actins A.; Rekis T.; Van Smaalen S.; Mishnev A. Polymorphism of R-Encenicline Hydrochloride: Access to the Highest Number of Structurally Characterized Polymorphs Using Desolvation of Various Solvates. Cryst. Growth Des. 2019, 19(8), 4765-4773.      

*Rubins U.; Marcinkevics Z.; Cimurs J.; Saknite I.; Kviesis-Kipge E.; Grabovskis A. Multimodal device for real-time monitoring of skin oxygen saturation and microcirculation function. Biosensors 2019, 9(3).      

Spura J.; Farhati A.; *Romanovs V.; Borodulin A.; Beļakovs S.; Popelis J.; Shestakova I.; Dammak M.; Jouikov V. Novel R3M (M = Si, Ge) substituted furan and thiophene-derived aldimines: Synthesis, electrochemistry, and biological activity Nouvelles aldimines dérivées du furanne et du thiophène substituées par R3M (M = Si, Ge): Synthèse, électrochimie et activité biologique. C. R. Chim. 2019, 22(9-10), 686-694.      

Sisulins A.; Bizdēna Ē.; Turks M.; *Novosjolova I. 2,6-bis[4-(4-butylphenyl)-1H-1,2,3-triazol-1-yl]-9- dodecyl-9H-purine. MolBank 2019, 2019(3).      

*Leonova E.; Ošiņa K.; Duburs G.; Bisenieks E.; Germini D.; Vassetzky Y.; Sjakste N. Metal ions modify DNA-protecting and mutagen-scavenging capacities of the AV-153 1,4-dihydropyridine. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2019, 845.      

De Angelis S.; Franco M.; Trimini A.; Gonzalez A.; Sainz R.; Degennaro L.; Romanazzi G.; Carlucci C.; Petrelli V.; de la Esperanza A.; Goni A.; Ferritto R.; *Acena J.L.; Luisi R.; Cid M.B. A Study of Graphene-Based Copper Catalysts: Copper(I) Nanoplatelets for Batch and Continuous-Flow Applications. Chem. Asian J. 2019, 14(17), 3011-3018.      

Melngaile R.; Sperga A.; Baldridge K.K.; *Veliks J. Diastereoselective monofluorocyclopropanation using fluoromethylsulfonium salts. Org. Lett. 2019, 21(17), 7174-7178.      

*Mohammadi P.; Sesilja Aranko A.; Landowski C.P.; Ikkala O.; Jaudzems K.; Wagermaier W.; Linder M.B. Biomimetic composites with enhanced toughening using silk-inspired triblock proteins and aligned nanocellulose reinforcements. Sci. Adv. 2019, 5(9).      

Terentjeva S.; Muceniece D.; *Lūsis V. Process-Related Impurities of Pazopanib. Org. Process Res. Dev. 2019, 23(9), 2057-2068.      

Briggs E.L.; Tota A.; Colella M.; Degennaro L.; *Luisi R.; Bull J.A. Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-amino-λ6-sulfanenitrile Intermediate. Angew. Chem. Int. Ed. 2019, 58(40), 14303-14310.      

Perry J.B.; Davis G.N.; Allen M.E.; Makrecka-Kuka M.; Dambrova M.; Grange R.W.; Shaikh S.R.; *Brown D.A. Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 2019, 135, 160-171.      

*Podolski-Renič A.; Dinič J.; Stankovič T.; Jovanovic M.; Ramovic A.; Pustenko A.; Žalubovskis R.; Pesic M. Sulfocoumarins, specific carbonic anhydrase IX and XII inhibitors, interact with cancer multidrug resistant phenotype through pH regulation and reverse P-glycoprotein mediated resistance. Eur. J. Pharm. Sci. 2019, 138.      

Keruckas J.; Volyniuk D.; Simokaitiene J.; Narbutaitis E.; Lazauskas A.; Lee P.-H.; Chiu T.-L.; Lin C.-F.; Arsenyan P.; Lee J.-H.; *Grazulevicius J.V. Methoxy- and tert-butyl-substituted meta-bis(N-carbazolyl)phenylenes as hosts for organic light-emitting diodes. Org. Electron 2019, 73, 317-326.      

Cousin S.F.; Liberman G.; Solomon E.; Otikovs M.; *Frydman L. A regularized reconstruction pipeline for high-definition diffusion MRI in challenging regions incorporating a per-shot image correction. Magn. Reson. Med. 2019, 82(4), 1322-1330.      

Xu P.; Ianes C.; Gartner F.; Liu C.; Burster T.; Bakulev V.; Rachidi N.; *Knippschild U.; Bischof J. Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D). Gene 2019, 715.      

*Švalbe B.; Stelfa G.; Vāvers E.; Zvejniece B.; Grinberga S.; Sevostjanovs E.; Pugovičs O.; Dambrova M.; Zvejniece L. Effects of the N-methyl-D-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration. Behav. Brain Res. 2019, 372.      

*Bobrovs R.; Jaudzems K.; Jirgensons A. Exploiting Structural Dynamics to Design Open-Flap Inhibitors of Malarial Aspartic Proteases. J. Med. Chem. 2019, 62(20), 8931-8950.      

Duchemin C.; Šmits G.; *Cramer N. RhI, IrIII,and CoIII Complexes with Atropchiral Biaryl Cyclopentadienyl Ligands: Syntheses, Structures, and Catalytic Activities. Organometallics 2019, 38(20), 4014-4021.      

*Kazakova O.B.; Smirnova I.E.; Medvedeva N.I.; Lopatina T.V.; Chudov I.V.; Sharipov A.R.; Ziganshin A.S.; Thao T.T.P. Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives. Russ. J. Bioorg. Chem. 2019, 45(6), 558-565.      

*Jēkabsone A.; Sile I.; Cochis A.; Makrecka-Kuka M.; Laucaityte G.; Makarova E.; Rimondini L.; Bernotiene R.; Raudone L.; Vedlugaite E.; Baniene R.; Smalinskiene A.; Savickiene N.; Dambrova M. Investigation of antibacterial and antiinflammatory activities of proanthocyanidins from pelargonium sidoides dc root extract. Nutrients 2019, 11(11).      

Jovanovic M.; Zhukovsky D.; Podolski-Renič A.; Domračeva I.; Žalubovskis R.; Sencanski M.; Glisic S.; Sharoyko V.; Tennikova T.; Dar'in D.; Pesic M.; *Krasavin M. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. Eur. J. Med. Chem. 2019, 181.      

Karpaviciene I.; Jonusis M.; Leduskrasts K.; Misiunaite I.; Suna E.; *Cikotiene I. Synthesis and photophysical properties of 3,5-diaryl-2-heteroarylthiophenes. Dyes Pigm. 2019, 170.      

Shafran Y.M.; Silaichev P.S.; *Bakulev V.A. β-(Cycloalkylamino)ethanesulfonyl azides as novel water-soluble reagents for the synthesis of diazo compounds and heterocycles. Chem. Heterocycl. Compd. 2019, 55(12), 1251-1261.      

*Cimurs J.; Brasovs A.; Erglis K. Stability analysis of a paramagnetic spheroid in a precessing field. J Magn Magn Mater 2019, 491.      

De Angelis S.; Celestini P.; Purgatorio R.; Degennaro L.; Rebuzzini G.; *Luisi R.; Carlucci C. Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction. J. Flow Chem. 2019, 9(4), 231-236.      

*Carlucci C.; Andresini M.; Degennaro L.; Luisi R. Benchmarking acidic and basic catalysis for a robust production of biofuel from waste cooking oil. Catalysts 2019, 9(12).      

Krukle-Berzina K.; Bērziņš K.; *Shubin K. Synthesis of some heptazine derivatives. Chem. Heterocycl. Compd. 2019, 55(12), 1281-1284.      

*Makrecka-Kuka M.; Korzh S.; Vilks K.; Vilšķērsts R.; Cīrule H.; Dambrova M.; Liepinsh E. Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia. Shock 2019, 52(6).      

*Švalbe B.; Grinberga S.; Stelfa G.; Vāvers E.; Zvejniece B.; Sevostjanovs E.; Dambrova M.; Zvejniece L. Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry. Data Brief 2019, 27.      

Zuhra K.; Sousa P.M.F.; Paulini G.; Lemos A.R.; Kalme Z.; Bisenieks I.; Bisenieks E.; Vigante B.; Duburs G.; Bandeiras T.M.; Saso L.; Giuffre A.; *Vicente J.B. Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods. Sci. Rep. 2019, 9(1).      

Makarova E.; Makrecka-Kuka M.; Vilks K.; Volska K.; Sevostjanovs E.; Grinberga S.; Žarkova-Malkova O.; Dambrova M.; *Liepinsh E. Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity. Front. Endocrinol. 2019, 10.      

Savitha B.; Reddy E.K.; Kumar C.S.A.; Karuvalam R.P.; Padusha M.S.A.; Bakulev V.A.; Narasimhamurthy K.H.; *Sajith A.M.; Joy M.N. A modified approach for the site-selective direct C-6 arylation of benzylated uracil. Tetrahedron Lett. 2019, 60(52).      

Patents and patent applications
Kalvins Ivars; Lebedevs Antons; Cernobrovijs Aleksandrs. A process for the preparation of lenalidomide. GB2535004, 02.01.2019.      

Arsenjans Pavels; Vasiljeva Jelena; Domracheva Ilona; Shestakova Irina; Pugovics Osvalds; Kalvins Ivars. Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents. BR112018073219, 22.01.2019.      

Stonans Ilmars; Misane Ilga; Svalbe Baiba; Dambrova Maija; Zvejniece Liga; Kalvins Ivars; Veinbergs Grigorijs; Cernobrovijs Aleksandrs; Vorona Maksims. Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures. JP6470870, 25.01.2019.      

Veinbergs Grigorijs; Kuznecovs Jevgenijs; Vorona Maksims; Domracheva Ilona; Leonciks Ainars; Kanepe-Lapsa Iveta. 1-Acetil-5-nitro-4-fenil-3-pirolin-2-ons pielietosanai veza arstesana. WO2019021067, 31.01.2019.      

Timofejeva Irena; Kozlovska Tatjana; Vezane Aleksandra; Apsite Gunita; Ose-Klinklava Velta; Bruvere Ruta; Vigante Brigita; Plotniece Aiva; Bisenieks Egils; Duburs Gunars. Jauni biologiski aktivi enaminoesteru atvasinajumi ka lidzekli kimijterapijai. LV15347, 20.02.2019.      

Wikberg Jarl; Liepins Edvards; Jirgensons Aigars. Novel compounds, their manufacture and uses (II). PL2807170, 13.03.2019.      

Wikberg Jarl; Liepins Edvards; Jirgensons Aigars. Novel compounds, their manufacture and uses (II). EP2807170, 13.03.2019.      

Jirgensons Aigars; Loza Einars; Charlton Michael; William Finn Paul; Edmund Grace. 2-Amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl TRNA synthetase. CA3038892, 12.04.2019.      

Veinbergs Grigorijs; Kuznecovs Jevgenijs; Vorona Maksims; Domracheva Ilona; Leonciks Ainars; Kanepe-Lapsa Iveta. 1-Acetil-5-nitro-4-fenil-3-pirolin-2-ons pielietosanai veza arstesana. LV15384, 20.05.2019.      

Arsenjans Pavels; Vasiljeva Jelena; Domracheva Ilona; Shestakova Irina; Kalvins Ivars. Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents. EP3487859, 29.05.2019.      

Jirgensons Aigars; Loza Einars; Charlton Michael; William Finn Paul; Edmund Grace. 2-Amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl TRNA synthetase. BR112019006943, 02.07.2019.      

Jirgensons Aigars; Loza Einars; Charlton Michael; William Finn Paul; Edmund Grace. 2-Amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl TRNA synthetase. BR112019006943, 02.07.2019.      

Arsenjans Pavels; Vasiljeva Jelena; Domracheva Ilona; Shestakova Irina; Pugovics Osvalds; Kalvins Ivars. Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents. AU2016415412, 11.07.2019.      

Jirgensons Aigars; Loza Einars; Charlton Michael; William Finn Paul; Edmund Grace. 2-Amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl TRNA synthetase. CN110049970, 23.07.2019.      

Arsenjans Pavels; Vasiljeva Jelena; Domracheva Ilona; Shestakova Irina; Kalvins Ivars. Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents. EA201990311, 31.07.2019.      

Jirgensons Aigars; Loza Einars; Charlton Michael; William Finn Paul; Edmund Grace. 2-Amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl TRNA synthetase. EP3523282, 14.08.2019.      

Wikberg Jarl; Liepins Edvards; Jirgensons Aigars. Novel compounds, their manufacture and uses (II). ES2723248, 22.08.2019.      

Arsenjans Pavels; Vasiljeva Jelena; Domracheva Ilona; Shestakova Irina; Pugovics Osvalds; Kalvins Ivars. Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents. JP2019523230, 22.08.2019.      

Arsenjans Pavels; Vasiljeva Jelena; Domracheva Ilona; Shestakova Irina; Pugovics Osvalds; Kalvins Ivars. Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents. US2019298758, 03.10.2019.      

Other publications
Spārītis O.; Kalviņš I.; Trapencieris P. IN MEMORIAM. Jānis Stradiņš (1933-2019). Chem. Heterocycl. Compd. 2019, 55(12), 1285-1286.      

Петухов В.И.; Дмитриев Е.В.; Баумане Л.Х.; Скальный A.B. CИНХРОННОСТЬ РАБОТЫ МЕМБРАННЫХ ПОМП В ЭПИДЕРМИСЕ: ВОЗМОЖНОСТЬ КОЛИЧЕСТВЕННОЙ ОЦЕНКИ УРОВНЯ СИНХРОНИЗАЦИИ. Новые информационные технологии в медицине, биологии, фармакологии и экологии 2019(eLIBRARY ID: 38571275 , УДК: 577.3), 248-252.      

Jaudzems K.; Petrova M. IN MEMORIAM Edvards Liepins (1944-2019). Chem. Heterocycl. Compd. 2019, 55(7), 688.      

*Krauze A.; Grīnberga S.; Domracheva I.; Duburs G. Synthesis of 6-aroylmethylsulfinyl-1,4-dihydropyridines as potential multidrug resistance modulators. Heterocyclic Letters 2019, 9(1), 21-26.