New studies in the field of new RNA-binders

Research on the synthesis and RNA-binding properties of extended nucleobases for triplex-forming peptide nucleic acids by Dr. Martins Katkevics group (Latvian Institute of Organic Synthesis) and professor Eriks Rozners lab (Binghamton University) has been published in the Journal of Organic Chemistry (IF 4.745, 2018).

Ilze Kumpina, Nikita Brodyagin, James A. MacKay, Scott D. Kennedy, Martins Katkevics, Eriks Rozners.
Synthesis and RNA-Binding Properties of Extended Nucleobases for Triplex-Forming Peptide Nucleic Acids.
J. Org. Chem. 2019, DOI:  10.1021/acs.joc.9b01133


This work was supported by the Latvian Institute of Organic Synthesis, internal research fund IG-2018-04, and the U.S. National Science Foundation grants CHE-1708761 to E.R. and CHE-1708699 to J.A.M.

New research in the field of purely organic luminescent materials

Prof. Suna (LIOS) group recently started a new research direction in the field of purely organic luminescent materials. The latest research on the design of aggregation induced emission luminogens is published in the journal Chemical Communications (Impact factor: 6.164):

Kaspars Leduskrasts,  Artis Kinens, Edgars Suna
Cation–π interactions secure aggregation induced emission of planar organic luminophores.
Chem. Commun., 2019, DOI: 10.1039/C9CC06829E

The research has showed that the use of non-covalent intermolecular π+–π interactions between quaternary pyridinium or imidazolium cations and aromatic π systems is an efficient approach to achieve AIE in planar purely organic luminophores.

Alliance4Life Formalizes its Existence


Today, on 4th October 2019, the founding members of the Alliance4Life gathered at Vilnius University and signed the Memorandum of Understanding, which formalizes the alliance as a permanent structure. The Alliance4Life connects progressive life science institutions from Central and Eastern Europe. The mission of the Alliance4Life shall be to support and strengthen European research excellence and the impact of scientific research on society, human health, and quality of life. The signing of the memorandum is the crown jewel of Alliance4Life´s achievements during the past two years of its existence. It symbolizes the partners’ commitment to make this alliance a long lasting one, for the benefit of the members and the whole region.

The formal existence of the Alliance4Life is in line with the current shift of the EU research policy towards a more sensitive approach to research and innovation needs of the Central and Eastern European countries. The Alliance4Life´s voice has been heard also during the new Horizon Europe negotiations, and surely will be listened to in the future. Alliance4Life intends to become a role model for institutions in less performing regions and to serve as a hub of excellence, inspiring others.


The Alliance4Life started two years ago as a project initiated by CEITEC Masaryk University with the clear mission to help close the innovation gap. Benchmarking exercises served as a starting point for development strategies for all seven focus groups – science evaluation, ethics and integrity, human resources and mobility, grants and funding, core facilities, knowledge and technology transfer, and science communication. The project enabled the members to gather for joint trainings and to develop best practice inventory, representing an enormous value for the members. During this meeting hosted by Vilnius University, all members confirmed that progress was made and a solid strategy was developed to be implemented in the years to come!

Masaryk University (CEITEC – Central European Institute of Technology) CZ
St. Anne’s University Hospital Brno (ICRC – International Clinical Research Center) CZ
Biomedical Research Center of the Slovak Academy of Sciences SK
Medical University of Lodz PL
University of Zagreb School of Medicine HR
University of Tartu EE
Vilnius University – Faculty of Medicine LT
Latvian Institute of Organic Synthesis LV
University of Ljubljana SI
SU Semmelweis University HU
EU-FLAG_cmyk_304dpi_small The project “Alliance for Life Sciences: Closing Research and Innovation Divide in
the European Union” received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 779303.


11th Paul Walden Symposium

On September 19-20, 2019 in the centre of Riga the 11th Paul Walden Symposium took place.

The Paul Walden Symposium on Organic Chemistry in Riga has become a tradition. It brings together scientists, scholars, and students from universities, research institutes, and industry from the Baltic States in Paul Walden’s homeland.

The program for Symposium was composed of plenary lectures by distinguished speakers and a poster session by the students.

8 prominent and respected lecturers from 4 countries – Jeffrey W. Bode, P. Andrew Evans, Burkhard Kőnig, Benjamin List, Herbert Mayr, Joseph Moran, Jerome Waser, and Daniel B. Werz gave lectures on their outstanding research in the field of organic chemistry.


The Symposium was opened with a Paul Walden medal presentation. In 2019 the medal for research in the field of organic methodology was awarded to Professor Aigars Jirgensons (Latvian Institute of Organic Synthesis) by Professor Māris Turks, Dean of the Faculty of Materials Science and Applied Chemistry (Riga Technical University). Professor Jirgensons later gave a lecture on the carbocation chemistry.

For two best Latvian PhD students there was an opportunity to give oral presentations on their research. This year the presentations were by Anna Lielpētere and Jurijs Ponomarjovs.

The poster prizes for the best posters (2 for PhD, 2 for MSc and 1 for BSc program students) were awarded by the chemical reagent company Bapeks (Dr. chem. Vilnis Liepiņš).

PhD students Sindija Lapčinska and Viktorija Vitkovska, MsC students Andris Jeminejs and Armands Kazia and BSc student Māris Bazulis were the recipients.

The Symposium was organized by the Latvian Institute of Organic Synthesis and the Riga Technical University.

Supported by the European Regional Development Fund “Support for international cooperation projects in research and innovation in Latvian Institute of Organic Synthesis”, contract No.

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Just released article on the synthesis of fluorocyclopropanes using fluoromethylsulfonium reagent

The research on the synthesis of fluorocyclopropanes using fluoromethylsulfonium reagent from LIOS has been published in the ACS journal “Organic Letters” (IF 6.555):

Renate Melngaile, Arturs Sperga, Kim K. Baldridge, Janis Veliks.
Diastereoselective Monofluorocyclopropanation Using Fluoromethylsulfonium Salts.
Org. Lett. 2019, DOI: 10.1021/acs.orglett.9b02867


Recent publication in the field of process chemistry

Dr. Viesturs Lusis group (LIOS) study on the synthesis of impurities as reference compounds for HPLC analysis, produced in Pazopanib synthesis is published in the ACS journal “Organic Process Research and Development” (IF 3.327):

Svetlana Terentjeva, Dzintra Muceniece, Viesturs Lusis.
Process-Related Impurities of Pazopanib.
Org. Process Res. Dev. 2019, DOI: 10.1021/acs.oprd.9b00117


New publication in the field of enantioselective catalysis

Research in the field of enantioselective catalysis performed by researchers from LIOS (Dr. Gints Šmits) and Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL) has been published in the journal Organometallics (IF=4.1, 2018):

Coralie Duchemin, Gints Smits, Nicolai Cramer
RhI, IrIII ,and CoIII Complexes with Atropchiral Biaryl Cyclopentadienyl Ligands: Syntheses, Structures, and Catalytic Activities,
DOI: 10.1021/acs.organomet.9b00365


Sulfocoumarins as a promising class of cancer-associated carbonic anhydrase inhibitors

Research of Prof. R. Žalubovskis group (LIOS) and scientists from Serbia (Institute for Biological Research “Sinisa Stankovic”, State University of Novi ) has been published in European Journal of Pharmaceutical Sciences (IF 3.532, 2018) on sulfocoumarins as a promising class of cancer-associated carbonic anhydrase inhibitors.

Ana Podolski-Renić,Jelena Dinić,Tijana Stanković, Mirna Jovanović, Amra Ramović, Aleksandrs Pustenko, Raivis Žalubovskisc, Milica Pešić.

Sulfocoumarins, specific carbonic anhydrase IX and XII inhibitors, interact with cancer multidrug resistant phenotype through pH regulation and reverse P-glycoprotein mediated resistance.

Eur. J. Pharm. Sci. 138, 2019, 105012; DOI: 10.1016/j.ejps.2019.105012


New approach for peptide functionalization

Dr. Pavel Arsenyan group showed a new approach for peptide functionalization through the generation of selenocysteine electrophile. This method is published in the European Journal of Organic Chemistry (IF 3.029):

Pavel Arsenyan, Sindija Lapcinska, Anna Ivanova, Jelena Vasiljeva.
Peptide Functionalization Through the Generation of Selenocysteine Electrophile.
Eur. J. Org. Chem., 2019, DOI: 10.1002/ejoc.201900907.


This article is devoted to the memory of Professor Edvards Liepinsh (1944–2019).

New article in the field of OLEDs

The joint article from Pavel Arsenyan (LIOS), Alla Petrenko (LIOS), Karolis Leitonas, Dmytro Volyniuk, Jurate Simokaitiene, Tomas Klinavičius, Eigirdas Skuodis, Jiun-Haw Lee, Juozas Vidas Gražulevičius on new iridium(III) complexes containing a 2-(benzo[b]selenophen-2-yl)pyridine ligand has been published in the journal “Inorganic Chemistry” (Impact Factor 4.85).

Synthesis and Performance in OLEDs of Selenium-Containing Phosphorescent Emitters with Red Emission Color Deeper Than the Corresponding NTSC Standard.

Inorg. Chem. 2019, 58, 15, 10174-10183. DOI: 10.1021/acs.inorgchem.9b01283