Laboratory of Membrane active Compounds and β-diketones

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Dr.chem.habil. Gunārs Duburs
Head of laboratory
e-mail:
Phone: (+371) 67014946

Recent publications

  1. Smits R.; Turovska B.; Belyakov S.; Plotniece A.; Duburs G. Synthesis of 5-carboxy-6-methyl-3,4-dihydro-2(1H)-pyridone derivatives and their electrochemical oxidation to 2-pyridones.  Chem. Phys. Lett. 2016, 649, 84-87.
  2. Velena A.; Zarkovic N.; Gall-Troselj K.; Bisenieks E.; Krauze A.; Poikans J.; Duburs G. 1,4-Dihydropyridine Derivatives – Dihydronicotinamide Analogues: Model Compounds Targeting Oxidative Stress. Oxidative Medicine and Cellular Longevity 2016, Article ID1892412, pp 35.
  3. Vigante B.; Rucins M.; Plotniece A.; Pajuste K.; Luntēna I.; Cekavičus B.; Bisenieks E.; Smits R.; Duburs G.; Sobolev A. Direct aminolysis of ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates. Molecules 2015, 20, 20341-20354.
  4. Rucins M.; Gosteva M.; Belyakov S.; Sobolev A.; Pajuste K.; Plotniece M.; Cekavicus B.; Tirzite D.; Plotniece A. Evaluation of antiradical activity and reducing capacity of synthesised bispyridinium dibromides obtained by quaternisation of 4-pyridyl-1,4-dihydropyridines with propargyl bromide.  J. Chem., 2015, 68, 86-92.
  5. Längle D., Marquardt V., Heider E., Vigante B., Duburs G., Luntena I., Flötgen D., Golz C., Strohmann C., Koch O., Schade D. Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ/Smad inhibitors. Eur. J. Med. Chem., 2015, 95, 249-66.
  6. Jansone B., Kadish I., van Groen T., Beitnere U., Moore D.R., Plotniece A., Pajuste K., Klusa V. A novel 1,4-dihydropyridine derivative improves spatial learning and memory and modifies brain protein expression in wild type and transgenic APPSweDI mice. PloS ONE 2015, 10(6): e0127686.