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Dr. habil. chem. Edgars Abele |
Modern Catalysis Method group was founded in 2003. The main directions of work included:
- Phase Transfer and Metal Complex catalysis;
- Elaboration of novel „green” bicatalytic sysems (phase transfer catalysis / ionic surfactants and transition metal catalyst in water) for the synthesis of biologically active heterocyclic systems;
- Synthesis of highly cytotoxic polycyclic heterocyclic compounds with low acute toxicity;
- Search of novel HIV integrase inhibitors which do not interfere with V(D)J recombination by modification of natural compounds.
Selected publications
- Abele E.; Abele R. Recent advances in the synthesis of heterocycles from oximes. Current Organic Synthesis 2014, 11, 403-428.
- Beresneva T.; Mishnev A.; Jaschenko E.; Shestakova I.; Gulbe A.; Abele E. Palladium-catalyzed synthesis of novel tetra- and penta-cyclic biologically active benzopyran- and pyridopyran-containing heterocyclic systems . ARKIVOC 2012, (ix), 185-194.
- Abele E.; Golomba L.; Beresneva T.; Visnevska J.; Jaschenko E.; Shestakova I.; Gulbe A.; Grinberga S.; Belyakov S.; Abele R. A new pathway for the preparation of biologically active 2-substituted 1,5-dihydrobenzo[e][1,2,4] oxadiazepines and related compounds by palladium-catalyzed cyclization of amidoximes with o-iodobenzyl bromide or 2-bromo-3-chloromethylpyridine. ARKIVOC 2012, (viii), 49-61.
- Beresneva T.; Abele E. Novel copper-catalyzed rearrangement of 2-aminobenzothiazoles to phenothiazines. Химия гетероцикл.соед. 2012(9), 1521-1524; Chem.Heterocycl. Comp. (Engl. Ed.). 2012, 48(9), 1420-1422.
- Visnevska J.; Belyakov S.; Abele E. A highly stereoselective synthesis of E-(but-1-en-3-yne-1-sulfonyl) hetarenes and disubstituted 2-benzothiazolyl alkynes by palladium catalyzed Sonogashira type coupling of 2-chlorovinylsulfones. Letters in Org. Chem. 2012, 9(4), 250-256.
- Lukevics E.; Abele E.; Ignatovich L. Biologically Active Silacyclanes. Adv. Heterocycl. Chem. 2010, 99, 107-141.