Laboratory of Membrane active Compounds and β-diketones

Pajuste_3_19.04.2018

 

Dr. chem. Kārlis Pajuste
Head of laboratory
e-mail:
Phone: (+371) 67014852

The main directions of the laboratory are the design and synthesis of biologically active heterocyclic systems, the design of synthetic lipids, encapsulation of drugs, DNA or RNA in a nanocarrier system and physico-chemical characterisation of nanoparticles.

Recent publications

  • Muhamadejev R.; Petrova M.; Smits R.; Plotniece A.; Pajuste K.; Duburs G.; Liepinsh E. Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques. New J. Chem. 2018, 42(9), 6942-6948.
  • Vigante B.; Plotniece A.; Ruciņš M.; Petrova M.; Muhamadejev R.; Pajuste K.; Belyakov S.; Shermolovich Y.G.; Sobolev A. An efficient synthesis of multisubstituted 4-nitrobuta-1,3-dien-1-amines and application in cyclisation reactions. Tetrahedron 2018, 74(21), 2596-2607.
  • Pikun N.V.; Kolesnyk N.P.; Rusanov E.B.; Plotniece A.; Ruciņš M.; Sobolev A.; Shermolovich Y.G. Synthesis of fluorinated 2,6-heptanediones and 2-oxa-6-azabicyclo[2.2.2]octanes from 1,4-dihydropyridines. Tetrahedron 2018, 74(23), 2884-2890.
  • Bruvere I.; Bisenieks E.; Poikans J.; Uldriķis J.; Plotniece A.; Pajuste K.; Ruciņš M.; Vigante B.; Kalme Z.; Gosteva M.; Domracheva I.; Velena A.; Vukovic T.; Milkovic L.; Duburs G.; Zarkovic N. Dihydropyridine derivatives as cell growth modulators in vitro. Oxidative Med. Cell. Longevity, 2017.
  • Velena A.; Zarkovic N.; Gall Troselj K.; Bisenieks E.; Krauze A.; Poikans J.; Duburs G. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues – Model Compounds Targeting Oxidative Stress. Oxidative Med. Cell. Longevity, 2016.
  • Smits R.; Turovska B.; Belyakov S.; Plotniece A.; Duburs G. Synthesis of 5-carboxy-6-methyl-3,4-dihydro-2(1H)-pyridone derivatives and their electrochemical oxidation to 2-pyridones. Chem. Phys. Lett. 2016, 649, 84-87.
  • Jansone B.; Kadish I.; van Groen T.; Beitnere U.; Plotniece A.; Pajuste K.; Kluša V. Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer’s disease transgenic female mice. Pharmacol. Res. 2016, 113, 781-787.
  • Langle D.; Marquardt V.; Heider E.; Vigante B.; Duburs G.; Luntena I.; Flotgen D.; Golz C.; Strohmann C.; Koch O.; Schade D. Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ2/Smad inhibitors. Eur. J. Med. Chem. 2015, 95, 249-266.
  • Petrichenko O.; Ruciņš M.; Vezane A.; Timofejeva I.; Sobolev A.; Čekavičus B.; Pajuste K.; Plotniece M.; Gosteva M.; Kozlovska T.; Plotniece A. Studies of the physicochemical and structural properties of self-assembling cationic pyridine derivatives as gene delivery agents. Chem. Phys. Lipids 2015, 191, 25-37.
  • Vigante B.; Ruciņš M.; Plotniece A.; Pajuste K.; Luntena I.; Čekavičus B.; Bisenieks E.; Smits R.; Duburs G.; Sobolev A. Direct aminolysis of ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates. Molecules 2015, 20(11), 20341-20354.

Selected patents

  • Duburs G.; Kalnins G.; Strods A.; Smits R.; Gulbe A.; Shestakova I. Jauni savienojumi efektīvai proteinu transfekcijai eikariotu šūnās. LV15073, 20.03.2016.
  • Kalvins I.; Krauze A.; Krasnova L.; Jaschenko E.; Andzans Z.; Shestakova I.; Duburs G.; Adlere I.; Domracheva I. Thieno[2,3-b]pyridines as multidrug resistance modulators. EP3008073, 20.04.2016.