Group of Experimental Chemical Therapy




Dr. chem. Ilona Domraceva
Group leader
Phone: (+371) 66155119

Experimental chemotherapy group is working in the field of in vitro and in vivo biological screening of novel compounds. Our aim is to find and utilize the most appropriate models for screening of compounds in the purpose to perform structure-activity relationship studies and to obtain more profound data about the possible mechanism of action. In twenty-year period the Experimental group of chemotherapy formed a large collection of various malignant and normal cell lines that are used in search of novel anti-cancer agents.

Selected recent publications

  1. Vasiljeva J.; Domracheva I.; Arsenyan P. Selenium analogues of (S)-clopidogrel: Preparation method and properties.Tetrahedron Lett. 2016 (57), 196-198.
  2. Arsenyan P.; Vasiljeva J.; Shestakova I.; Domracheva I.; Jaschenko E.; Romanchikova N.; Leonchik A.; Rudevica Z.; Belyakov S. Selenopheno[3,2-c]- and [2,3-c]coumarins: synthesis, cytotoxicity, angiogenesis inhibition, and antioxidant properties. Comptes Rendus Chimie. 2015, 18, 399-409.
  3. Domracheva I.; Muhamadejev R.; Petrova M.; Liepinsh E.; Gulbe A.; Shestakova I.; Duburs G.; Arsenyan P. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect. Toxicology Reports. 2015, 2, 377-383.
  4. Arsenyan P.; Paegle E.; Domracheva I.; Gulbe A.; Kanepe-Lapsa I.; Shestakova I. Selenium analogues of raloxifene as promising antiproliferative agents in treatment of breast cancer. Eur. J. Med. Chem. 2014, 87, 471-483.
  5. Zvejniece L., Vavers E., Svalbe B., Vilskersts R., Domracheva I., Vorona M., Veinberg G., Misane I., Stonans I., Kalvinsh I., Dambrova M. The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors. Br. J. Pharmacol. 2014, 171, 3, 761-771